Characterization of femtosecond laser-induced breakdown spectroscopy (fsLIBS) and applications for biological samples

Ruby K. Gill, Florian Knorr, Zachary J. Smith, Mehmet Kahraman, Dorte Madsen, Delmar S. Larsen, Sebastian Wachsmann-Hogiu

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


We characterize the femtosecond laser-induced breakdown spectroscopy (fsLIBS) signal for biological tissues as a function of different excitation parameters with femtosecond laser systems. These parameters include laser energy, depth of focus, and number of pulses per focal volume. We used femtosecond laser pulses of 800 nm and energy between 25 and 123 ),J to generate LIBS signals in biological tissues. As expected, we observed a linear increase in the fsLIBS intensity as a function of the laser energy. In addition, we show that moving the beam out of focus and the presence of overlapping pulses on the same focal area leads to a decrease in fsLIBS intensity due to changes in focal spot size. We also demonstrate that fsLIBS can distinguish between different biological tissue samples.

Original languageEnglish (US)
Pages (from-to)949-954
Number of pages6
JournalApplied Spectroscopy
Issue number9
StatePublished - Sep 1 2015


  • Femtosecond phenomena
  • Laser materials processing
  • Laser-induced breakdown spectroscopy
  • Libs
  • Optical diagnostics for medicine chemical analysis
  • Ultra-short pulsed laser

ASJC Scopus subject areas

  • Spectroscopy
  • Instrumentation
  • Medicine(all)


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