Characterization of femtosecond laser-induced breakdown spectroscopy (fsLIBS) and applications for biological samples

Ruby K. Gill; Florian Knorr; Zachary J. Smith; Mehmet Kahraman; Dorte Madsen; Delmar S. Larsen; Sebastian Wachsmann-Hogiu

doi:10.1366/13-07293

Characterization of femtosecond laser-induced breakdown spectroscopy (fsLIBS) and applications for biological samples

Ruby K. Gill, Florian Knorr, Zachary J. Smith, Mehmet Kahraman, Dorte Madsen, Delmar S. Larsen, Sebastian Wachsmann-Hogiu

Pathology and Laboratory Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

We characterize the femtosecond laser-induced breakdown spectroscopy (fsLIBS) signal for biological tissues as a function of different excitation parameters with femtosecond laser systems. These parameters include laser energy, depth of focus, and number of pulses per focal volume. We used femtosecond laser pulses of 800 nm and energy between 25 and 123 ),J to generate LIBS signals in biological tissues. As expected, we observed a linear increase in the fsLIBS intensity as a function of the laser energy. In addition, we show that moving the beam out of focus and the presence of overlapping pulses on the same focal area leads to a decrease in fsLIBS intensity due to changes in focal spot size. We also demonstrate that fsLIBS can distinguish between different biological tissue samples.

Original language	English (US)
Pages (from-to)	949-954
Number of pages	6
Journal	Applied Spectroscopy
Volume	68
Issue number	9
DOIs	https://doi.org/10.1366/13-07293
State	Published - Sep 1 2015

Keywords

Femtosecond phenomena
Laser materials processing
Laser-induced breakdown spectroscopy
Libs
Optical diagnostics for medicine chemical analysis
Ultra-short pulsed laser

ASJC Scopus subject areas

Spectroscopy
Instrumentation
Medicine(all)

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Characterization of femtosecond laser-induced breakdown spectroscopy (fsLIBS) and applications for biological samples. / Gill, Ruby K.; Knorr, Florian; Smith, Zachary J.; Kahraman, Mehmet; Madsen, Dorte; Larsen, Delmar S.; Wachsmann-Hogiu, Sebastian.

In: Applied Spectroscopy, Vol. 68, No. 9, 01.09.2015, p. 949-954.

Research output: Contribution to journal › Article › peer-review

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abstract = "We characterize the femtosecond laser-induced breakdown spectroscopy (fsLIBS) signal for biological tissues as a function of different excitation parameters with femtosecond laser systems. These parameters include laser energy, depth of focus, and number of pulses per focal volume. We used femtosecond laser pulses of 800 nm and energy between 25 and 123 ),J to generate LIBS signals in biological tissues. As expected, we observed a linear increase in the fsLIBS intensity as a function of the laser energy. In addition, we show that moving the beam out of focus and the presence of overlapping pulses on the same focal area leads to a decrease in fsLIBS intensity due to changes in focal spot size. We also demonstrate that fsLIBS can distinguish between different biological tissue samples.",

keywords = "Femtosecond phenomena, Laser materials processing, Laser-induced breakdown spectroscopy, Libs, Optical diagnostics for medicine chemical analysis, Ultra-short pulsed laser",

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AU - Gill, Ruby K.

AU - Knorr, Florian

AU - Smith, Zachary J.

AU - Kahraman, Mehmet

AU - Madsen, Dorte

AU - Larsen, Delmar S.

AU - Wachsmann-Hogiu, Sebastian

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N2 - We characterize the femtosecond laser-induced breakdown spectroscopy (fsLIBS) signal for biological tissues as a function of different excitation parameters with femtosecond laser systems. These parameters include laser energy, depth of focus, and number of pulses per focal volume. We used femtosecond laser pulses of 800 nm and energy between 25 and 123 ),J to generate LIBS signals in biological tissues. As expected, we observed a linear increase in the fsLIBS intensity as a function of the laser energy. In addition, we show that moving the beam out of focus and the presence of overlapping pulses on the same focal area leads to a decrease in fsLIBS intensity due to changes in focal spot size. We also demonstrate that fsLIBS can distinguish between different biological tissue samples.

AB - We characterize the femtosecond laser-induced breakdown spectroscopy (fsLIBS) signal for biological tissues as a function of different excitation parameters with femtosecond laser systems. These parameters include laser energy, depth of focus, and number of pulses per focal volume. We used femtosecond laser pulses of 800 nm and energy between 25 and 123 ),J to generate LIBS signals in biological tissues. As expected, we observed a linear increase in the fsLIBS intensity as a function of the laser energy. In addition, we show that moving the beam out of focus and the presence of overlapping pulses on the same focal area leads to a decrease in fsLIBS intensity due to changes in focal spot size. We also demonstrate that fsLIBS can distinguish between different biological tissue samples.

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KW - Laser materials processing

KW - Laser-induced breakdown spectroscopy

KW - Libs

KW - Optical diagnostics for medicine chemical analysis

KW - Ultra-short pulsed laser

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Characterization of femtosecond laser-induced breakdown spectroscopy (fsLIBS) and applications for biological samples

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Keywords

ASJC Scopus subject areas

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