Characterization of epistasis influencing complex spontaneous obesity in the BSB model

Nengjun Yi, Adam Diament, Sally Chiu, Kyoungmi Kim, David B. Allison, Janis S. Fisler, Craig H Warden

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

There is growing awareness that complex interactions among multiple genes and environmental factors play an important role in controlling obesity traits. The BSB mouse, which is produced by the backcross of (lean C57BL/6J × lean Mus spretus) × C57BL/6J, provides an excellent model of epistatic obesity. To evaluate potential epistatic interactions among six chromosomal regions previously determined to influence obesity phenotypes, we performed novel Bayesian analyses on the basis of both epistatic and nonepistatic models for four obesity traits: percentage of body fat, adiposity index, total fat mass, and body weight, and also for plasma total cholesterol. The epistatic analysis detected at least one more QTL than the nonepistatic analysis did for all obesity traits. These obesity traits were variously influenced by QTL on chromosomes 2, 7, 12, 15, and 16. Interaction between genes on chromosomes 2 and 12 was present for all obesity traits, accounting for 3-4.8% of the phenotypic variation. Chromosome 12 was found to have weak main effects on all obesity traits. Several different epistatic interactions were also detected for percentage of body fat, adiposity index, and total fat mass. Chromosomes 6 and 12 have not only main effects but also strong epistatic effects on plasma total cholesterol. Our results emphasize the importance of modeling epistasis for discovery of obesity genes.

Original languageEnglish (US)
Pages (from-to)399-409
Number of pages11
JournalGenetics
Volume167
Issue number1
DOIs
StatePublished - May 2004

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Obesity
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 2
Adiposity
Adipose Tissue
Fats
Cholesterol
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 7
Bayes Theorem
Genetic Association Studies
Genes
Body Weight
Phenotype

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Characterization of epistasis influencing complex spontaneous obesity in the BSB model. / Yi, Nengjun; Diament, Adam; Chiu, Sally; Kim, Kyoungmi; Allison, David B.; Fisler, Janis S.; Warden, Craig H.

In: Genetics, Vol. 167, No. 1, 05.2004, p. 399-409.

Research output: Contribution to journalArticle

Yi, Nengjun ; Diament, Adam ; Chiu, Sally ; Kim, Kyoungmi ; Allison, David B. ; Fisler, Janis S. ; Warden, Craig H. / Characterization of epistasis influencing complex spontaneous obesity in the BSB model. In: Genetics. 2004 ; Vol. 167, No. 1. pp. 399-409.
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