Characterization of CD4+ T cell responses during natural infection with Salmonella typhimurium

Stephen J Mcsorley, Brad T. Cookson, Marc K. Jenkins

Research output: Contribution to journalArticle

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Abstract

CD4+ T cells are important for resistance to infection with Salmonella typhimurium. However, the Ag specificity of this T cell response is unknown. Here, we demonstrate that a significant fraction of Salmonella-specific CD4+ T cells respond to the flagellar filament protein, FliC, and that this Ag has the capacity to protect naive mice from lethal Salmonella infection. To characterize this Ag-specific response further, we generated FliC-specific CD4+ T cell clones from mice that had resolved infection with an attenuated strain of Salmonella. These clones were found to respond to an epitope from a constant region of FliC, enabling them to cross-react with flagellar proteins expressed by a number of distinct Salmonella serovars.

Original languageEnglish (US)
Pages (from-to)986-993
Number of pages8
JournalJournal of Immunology
Volume164
Issue number2
StatePublished - Jan 15 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology

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