Characterization of an endogenous retrovirus-repetitive DNA chimera in the mouse genome

T. G. Fanning, D. W. Morris, Robert Cardiff, H. D. Bradshaw

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We found that an endogenous mouse mammary tumor provirus, GR-MTV-8, is embedded within a member of the BAM HI family of long interspersed repetitive mouse DNAs. GR-MTV-8 appears to be transcriptionally silent at its normal chromosomal position in the mouse genome. The provirus is transcriptionally active, however, when cloned and transfected into mouse cells (Kennedy et al., Nature (London) 295:622-624, 1982). We propose that the transcriptional inactivity of GR-MTV-8 in situ is due to an inhibitory effect, possibly involving DNA methylation, attributable to the flanking BAM HI element.

Original languageEnglish (US)
Pages (from-to)998-1000
Number of pages3
JournalJournal of Virology
Volume53
Issue number3
StatePublished - Jan 1 1985

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Retroviridae
Endogenous Retroviruses
chimerism
Genome
proviruses
Proviruses
genome
DNA
mice
mammary neoplasms (animal)
DNA methylation
DNA Methylation
Breast Neoplasms
cells

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Characterization of an endogenous retrovirus-repetitive DNA chimera in the mouse genome. / Fanning, T. G.; Morris, D. W.; Cardiff, Robert; Bradshaw, H. D.

In: Journal of Virology, Vol. 53, No. 3, 01.01.1985, p. 998-1000.

Research output: Contribution to journalArticle

Fanning, TG, Morris, DW, Cardiff, R & Bradshaw, HD 1985, 'Characterization of an endogenous retrovirus-repetitive DNA chimera in the mouse genome', Journal of Virology, vol. 53, no. 3, pp. 998-1000.
Fanning, T. G. ; Morris, D. W. ; Cardiff, Robert ; Bradshaw, H. D. / Characterization of an endogenous retrovirus-repetitive DNA chimera in the mouse genome. In: Journal of Virology. 1985 ; Vol. 53, No. 3. pp. 998-1000.
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