Characterization of a spontaneous disease of white leghorn chickens resembling progressive systemic sclerosis (scleroderma)

M. Eric Gershwin, H. Abplanalp, J. J. Castles, R. M. Ikeda, J. van der Water, J. Eklund, D. Haynes

Research output: Contribution to journalArticle

76 Scopus citations

Abstract

University of California, Davis (UCD) line 200 White Leghorn Chickens spontaneously develop a syndrome that has many analogous features to human progressive systemic sclerosis. This syndrome is characterized by progressive involution of comb, dermal fibrosis, and distal polyarthritis. These three features occur within 6 wk after hatching, and are accompanied by a 40% mortality as a result of vaso-occlusive disease, with development of secondary infection of peripheral gangrenous lesions. Birds that survive >2 mo after hatching progressively develop fibrosis of the esophagous and mononuclear infiltration of heart and kidney, with prominent occlusion of small and medium sized blood vessels. In addition, line 200 chickens develop rheumatoid factors, antinuclear antibodies, and antibodies to collagen, but do not have antibodies to thymocytes, DNA, or extractable nuclear antigens. Moreover, antinuclear antibodies when studied using HEp-2 cells as substrate demonstrate predominantly a speckled pattern. This syndrome of line 200 chickens is not detectable in F 1 crosses to several UCD inbred lines. F 1 x parenteral line BC 1 backcrosses have an ~50% incidence of disease, suggesting that this syndrome is inherited as autosomal recessive. However, only 4% of F 2 generation birds show abnormal symptoms, suggesting the presence of modifying genes. There is no appearance of IgG deposition, as determined by immunofluorescence, in either skin, blood vessels, esophagus, or heart. However, ~20% of chickens have a glomerulonephritis; this feature appears to be a terminal event and does not appear clinically significant. Although this syndrome of line 200 chickens has several features that are in sharp distinction to human scleroderma, the presence of common immunologic and pathologic denominators suggest that this spontaneous disease may be an appropriate model to develop a better understanding of autoimmune connective tissue diseases.

Original languageEnglish (US)
Pages (from-to)1640-1659
Number of pages20
JournalJournal of Experimental Medicine
Volume153
Issue number6
DOIs
StatePublished - 1981

ASJC Scopus subject areas

  • Immunology

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