Characterization of a feline influenza A(H7N2) virus

Masato Hatta, Gongxun Zhong, Yuwei Gao, Noriko Nakajima, Shufang Fan, Shiho Chiba, Kathleen M. Deering, Mutsumi Ito, Masaki Imai, Maki Kiso, Sumiho Nakatsu, Tiago J. Lopes, Andrew J. Thompson, Ryan McBride, David L. Suarez, Catherine A. Macken, Shigeo Sugita, Gabriele Neumann, Hideki Hasegawa, James C. PaulsonKathy L. Kurth, Yoshihiro Kawaoka

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

During December 2016-February 2017, influenza A viruses of the H7N2 subtype infected ≈500 cats in animal shelters in New York, NY, USA, indicating virus transmission among cats. A veterinarian who treated the animals also became infected with feline influenza A(H7N2) virus and experienced respiratory symptoms. To understand the pathogenicity and transmissibility of these feline H7N2 viruses in mammals, we characterized them in vitro and in vivo. Feline H7N2 subtype viruses replicated in the respiratory organs of mice, ferrets, and cats without causing severe lesions. Direct contact transmission of feline H7N2 subtype viruses was detected in ferrets and cats; in cats, exposed animals were also infected via respiratory droplet transmission. These results suggest that the feline H7N2 subtype viruses could spread among cats and also infect humans. Outbreaks of the feline H7N2 viruses could, therefore, pose a risk to public health.

Original languageEnglish (US)
Pages (from-to)75-86
Number of pages12
JournalEmerging Infectious Diseases
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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  • Cite this

    Hatta, M., Zhong, G., Gao, Y., Nakajima, N., Fan, S., Chiba, S., Deering, K. M., Ito, M., Imai, M., Kiso, M., Nakatsu, S., Lopes, T. J., Thompson, A. J., McBride, R., Suarez, D. L., Macken, C. A., Sugita, S., Neumann, G., Hasegawa, H., ... Kawaoka, Y. (2018). Characterization of a feline influenza A(H7N2) virus. Emerging Infectious Diseases, 24(1), 75-86. https://doi.org/10.3201/eid2401.171240