Characterization of a feline influenza A(H7N2) virus

Masato Hatta; Gongxun Zhong; Yuwei Gao; Noriko Nakajima; Shufang Fan; Shiho Chiba; Kathleen M. Deering; Mutsumi Ito; Masaki Imai; Maki Kiso; Sumiho Nakatsu; Tiago J. Lopes; Andrew J. Thompson; Ryan McBride; David L. Suarez; Catherine A. Macken; Shigeo Sugita; Gabriele Neumann; Hideki Hasegawa; James C. Paulson; Kathy L. Kurth; Yoshihiro Kawaoka

doi:10.3201/eid2401.171240

Characterization of a feline influenza A(H7N2) virus

Masato Hatta, Gongxun Zhong, Yuwei Gao, Noriko Nakajima, Shufang Fan, Shiho Chiba, Kathleen M. Deering, Mutsumi Ito, Masaki Imai, Maki Kiso, Sumiho Nakatsu, Tiago J. Lopes, Andrew J. Thompson, Ryan McBride, David L. Suarez, Catherine A. Macken, Shigeo Sugita, Gabriele Neumann, Hideki Hasegawa, James C. PaulsonKathy L. Kurth, Yoshihiro Kawaoka

Research output: Contribution to journal › Article

10 Scopus citations

Abstract

During December 2016-February 2017, influenza A viruses of the H7N2 subtype infected ≈500 cats in animal shelters in New York, NY, USA, indicating virus transmission among cats. A veterinarian who treated the animals also became infected with feline influenza A(H7N2) virus and experienced respiratory symptoms. To understand the pathogenicity and transmissibility of these feline H7N2 viruses in mammals, we characterized them in vitro and in vivo. Feline H7N2 subtype viruses replicated in the respiratory organs of mice, ferrets, and cats without causing severe lesions. Direct contact transmission of feline H7N2 subtype viruses was detected in ferrets and cats; in cats, exposed animals were also infected via respiratory droplet transmission. These results suggest that the feline H7N2 subtype viruses could spread among cats and also infect humans. Outbreaks of the feline H7N2 viruses could, therefore, pose a risk to public health.

Original language	English (US)
Pages (from-to)	75-86
Number of pages	12
Journal	Emerging Infectious Diseases
Volume	24
Issue number	1
DOIs	https://doi.org/10.3201/eid2401.171240
State	Published - Jan 1 2018
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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Hatta, M., Zhong, G., Gao, Y., Nakajima, N., Fan, S., Chiba, S., Deering, K. M., Ito, M., Imai, M., Kiso, M., Nakatsu, S., Lopes, T. J., Thompson, A. J., McBride, R., Suarez, D. L., Macken, C. A., Sugita, S., Neumann, G., Hasegawa, H., ... Kawaoka, Y. (2018). Characterization of a feline influenza A(H7N2) virus. Emerging Infectious Diseases, 24(1), 75-86. https://doi.org/10.3201/eid2401.171240

Characterization of a feline influenza A(H7N2) virus. / Hatta, Masato; Zhong, Gongxun; Gao, Yuwei; Nakajima, Noriko; Fan, Shufang; Chiba, Shiho; Deering, Kathleen M.; Ito, Mutsumi; Imai, Masaki; Kiso, Maki; Nakatsu, Sumiho; Lopes, Tiago J.; Thompson, Andrew J.; McBride, Ryan; Suarez, David L.; Macken, Catherine A.; Sugita, Shigeo; Neumann, Gabriele; Hasegawa, Hideki; Paulson, James C.; Kurth, Kathy L.; Kawaoka, Yoshihiro.

In: Emerging Infectious Diseases, Vol. 24, No. 1, 01.01.2018, p. 75-86.

Research output: Contribution to journal › Article

Hatta, M, Zhong, G, Gao, Y, Nakajima, N, Fan, S, Chiba, S, Deering, KM, Ito, M, Imai, M, Kiso, M, Nakatsu, S, Lopes, TJ, Thompson, AJ, McBride, R, Suarez, DL, Macken, CA, Sugita, S, Neumann, G, Hasegawa, H, Paulson, JC, Kurth, KL & Kawaoka, Y 2018, 'Characterization of a feline influenza A(H7N2) virus', Emerging Infectious Diseases, vol. 24, no. 1, pp. 75-86. https://doi.org/10.3201/eid2401.171240

Hatta, Masato ; Zhong, Gongxun ; Gao, Yuwei ; Nakajima, Noriko ; Fan, Shufang ; Chiba, Shiho ; Deering, Kathleen M. ; Ito, Mutsumi ; Imai, Masaki ; Kiso, Maki ; Nakatsu, Sumiho ; Lopes, Tiago J. ; Thompson, Andrew J. ; McBride, Ryan ; Suarez, David L. ; Macken, Catherine A. ; Sugita, Shigeo ; Neumann, Gabriele ; Hasegawa, Hideki ; Paulson, James C. ; Kurth, Kathy L. ; Kawaoka, Yoshihiro. / Characterization of a feline influenza A(H7N2) virus. In: Emerging Infectious Diseases. 2018 ; Vol. 24, No. 1. pp. 75-86.

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abstract = "During December 2016-February 2017, influenza A viruses of the H7N2 subtype infected ≈500 cats in animal shelters in New York, NY, USA, indicating virus transmission among cats. A veterinarian who treated the animals also became infected with feline influenza A(H7N2) virus and experienced respiratory symptoms. To understand the pathogenicity and transmissibility of these feline H7N2 viruses in mammals, we characterized them in vitro and in vivo. Feline H7N2 subtype viruses replicated in the respiratory organs of mice, ferrets, and cats without causing severe lesions. Direct contact transmission of feline H7N2 subtype viruses was detected in ferrets and cats; in cats, exposed animals were also infected via respiratory droplet transmission. These results suggest that the feline H7N2 subtype viruses could spread among cats and also infect humans. Outbreaks of the feline H7N2 viruses could, therefore, pose a risk to public health.",

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