TY - GEN
T1 - Characteristics of the protective subcellular coccidioidal T27K vaccine
AU - Johnson, Suzanne M.
AU - Kerekes, Kathleen M.
AU - Lunetta, Jennine M.
AU - Pappagianis, Demosthenes
PY - 2007/9
Y1 - 2007/9
N2 - While the whole killed spherule vaccine, protective in mice and monkeys, did not prevent coccidioidal disease in humans, the 27K vaccine, a soluble derivative, retains protective activity in mice with little irritant action. Gel filtration and anion exchange fractions of thimerosal-inactivated spherules (T27K), when administered with alum adjuvant, also protect mice against lethal respiratory coccidioidal challenge. However, the superb protection afforded by T27K antigens is maintained for some 3 months, but may then diminish. This appears unrelated to the aging of the mice. Prolongation of the protective action may require addition of a different adjuvant or administration of booster doses of vaccine.
AB - While the whole killed spherule vaccine, protective in mice and monkeys, did not prevent coccidioidal disease in humans, the 27K vaccine, a soluble derivative, retains protective activity in mice with little irritant action. Gel filtration and anion exchange fractions of thimerosal-inactivated spherules (T27K), when administered with alum adjuvant, also protect mice against lethal respiratory coccidioidal challenge. However, the superb protection afforded by T27K antigens is maintained for some 3 months, but may then diminish. This appears unrelated to the aging of the mice. Prolongation of the protective action may require addition of a different adjuvant or administration of booster doses of vaccine.
KW - Adjuvant
KW - Anion exchange
KW - Coccidioidomycosis
KW - FPLC
KW - Gel filtration
KW - Immunization route
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=35348842060&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35348842060&partnerID=8YFLogxK
U2 - 10.1196/annals.1406.016
DO - 10.1196/annals.1406.016
M3 - Conference contribution
C2 - 17363436
AN - SCOPUS:35348842060
SN - 1573316881
SN - 9781573316880
VL - 1111
T3 - Annals of the New York Academy of Sciences
SP - 275
EP - 289
BT - Annals of the New York Academy of Sciences
ER -