Characteristics of the protective subcellular coccidioidal T27K vaccine

Suzanne M. Johnson; Kathleen M. Kerekes; Jennine M. Lunetta; Demosthenes Pappagianis

doi:10.1196/annals.1406.016

Characteristics of the protective subcellular coccidioidal T27K vaccine

Suzanne M. Johnson, Kathleen M. Kerekes, Jennine M. Lunetta, Demosthenes Pappagianis

Medical Microbiology and Immunology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

10 Scopus citations

Abstract

While the whole killed spherule vaccine, protective in mice and monkeys, did not prevent coccidioidal disease in humans, the 27K vaccine, a soluble derivative, retains protective activity in mice with little irritant action. Gel filtration and anion exchange fractions of thimerosal-inactivated spherules (T27K), when administered with alum adjuvant, also protect mice against lethal respiratory coccidioidal challenge. However, the superb protection afforded by T27K antigens is maintained for some 3 months, but may then diminish. This appears unrelated to the aging of the mice. Prolongation of the protective action may require addition of a different adjuvant or administration of booster doses of vaccine.

Original language	English (US)
Title of host publication	Annals of the New York Academy of Sciences
Pages	275-289
Number of pages	15
Volume	1111
DOIs	https://doi.org/10.1196/annals.1406.016
State	Published - Sep 2007

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1111
ISSN (Print)	00778923
ISSN (Electronic)	17496632

Keywords

Adjuvant
Anion exchange
Coccidioidomycosis
FPLC
Gel filtration
Immunization route
Vaccine

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1196/annals.1406.016

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Characteristics of the protective subcellular coccidioidal T27K vaccine. / Johnson, Suzanne M.; Kerekes, Kathleen M.; Lunetta, Jennine M.; Pappagianis, Demosthenes.

Annals of the New York Academy of Sciences. Vol. 1111 2007. p. 275-289 (Annals of the New York Academy of Sciences; Vol. 1111).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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abstract = "While the whole killed spherule vaccine, protective in mice and monkeys, did not prevent coccidioidal disease in humans, the 27K vaccine, a soluble derivative, retains protective activity in mice with little irritant action. Gel filtration and anion exchange fractions of thimerosal-inactivated spherules (T27K), when administered with alum adjuvant, also protect mice against lethal respiratory coccidioidal challenge. However, the superb protection afforded by T27K antigens is maintained for some 3 months, but may then diminish. This appears unrelated to the aging of the mice. Prolongation of the protective action may require addition of a different adjuvant or administration of booster doses of vaccine.",

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AB - While the whole killed spherule vaccine, protective in mice and monkeys, did not prevent coccidioidal disease in humans, the 27K vaccine, a soluble derivative, retains protective activity in mice with little irritant action. Gel filtration and anion exchange fractions of thimerosal-inactivated spherules (T27K), when administered with alum adjuvant, also protect mice against lethal respiratory coccidioidal challenge. However, the superb protection afforded by T27K antigens is maintained for some 3 months, but may then diminish. This appears unrelated to the aging of the mice. Prolongation of the protective action may require addition of a different adjuvant or administration of booster doses of vaccine.

KW - Adjuvant

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KW - Coccidioidomycosis

KW - FPLC

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KW - Immunization route

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Characteristics of the protective subcellular coccidioidal T27K vaccine

Abstract

Publication series

Keywords

ASJC Scopus subject areas

Access to Document

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