Abstract
While the whole killed spherule vaccine, protective in mice and monkeys, did not prevent coccidioidal disease in humans, the 27K vaccine, a soluble derivative, retains protective activity in mice with little irritant action. Gel filtration and anion exchange fractions of thimerosal-inactivated spherules (T27K), when administered with alum adjuvant, also protect mice against lethal respiratory coccidioidal challenge. However, the superb protection afforded by T27K antigens is maintained for some 3 months, but may then diminish. This appears unrelated to the aging of the mice. Prolongation of the protective action may require addition of a different adjuvant or administration of booster doses of vaccine.
| Original language | English (US) |
|---|---|
| Title of host publication | Annals of the New York Academy of Sciences |
| Pages | 275-289 |
| Number of pages | 15 |
| Volume | 1111 |
| DOIs | |
| State | Published - Sep 2007 |
Publication series
| Name | Annals of the New York Academy of Sciences |
|---|---|
| Volume | 1111 |
| ISSN (Print) | 00778923 |
| ISSN (Electronic) | 17496632 |
Keywords
- Adjuvant
- Anion exchange
- Coccidioidomycosis
- FPLC
- Gel filtration
- Immunization route
- Vaccine
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Fingerprint Dive into the research topics of 'Characteristics of the protective subcellular coccidioidal T27K vaccine'. Together they form a unique fingerprint.
Cite this
Johnson, S. M., Kerekes, K. M., Lunetta, J. M., & Pappagianis, D. (2007). Characteristics of the protective subcellular coccidioidal T27K vaccine. In Annals of the New York Academy of Sciences (Vol. 1111, pp. 275-289). (Annals of the New York Academy of Sciences; Vol. 1111). https://doi.org/10.1196/annals.1406.016