Characteristics of the protective subcellular coccidioidal T27K vaccine

Suzanne M. Johnson, Kathleen M. Kerekes, Jennine M. Lunetta, Demosthenes Pappagianis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations

Abstract

While the whole killed spherule vaccine, protective in mice and monkeys, did not prevent coccidioidal disease in humans, the 27K vaccine, a soluble derivative, retains protective activity in mice with little irritant action. Gel filtration and anion exchange fractions of thimerosal-inactivated spherules (T27K), when administered with alum adjuvant, also protect mice against lethal respiratory coccidioidal challenge. However, the superb protection afforded by T27K antigens is maintained for some 3 months, but may then diminish. This appears unrelated to the aging of the mice. Prolongation of the protective action may require addition of a different adjuvant or administration of booster doses of vaccine.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages275-289
Number of pages15
Volume1111
DOIs
StatePublished - Sep 2007

Publication series

NameAnnals of the New York Academy of Sciences
Volume1111
ISSN (Print)00778923
ISSN (Electronic)17496632

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Keywords

  • Adjuvant
  • Anion exchange
  • Coccidioidomycosis
  • FPLC
  • Gel filtration
  • Immunization route
  • Vaccine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Johnson, S. M., Kerekes, K. M., Lunetta, J. M., & Pappagianis, D. (2007). Characteristics of the protective subcellular coccidioidal T27K vaccine. In Annals of the New York Academy of Sciences (Vol. 1111, pp. 275-289). (Annals of the New York Academy of Sciences; Vol. 1111). https://doi.org/10.1196/annals.1406.016