Characteristics of gut specific monoclonal antibodies

Research output: Contribution to journalArticle

Abstract

Eight distinct murine monoclonal antibodies that are directed to normal human mouse small intestinal epithelial cells have been characterized. Three of these called TPNG 2, 20 and 43 were directed to goblet cells and mucin components. One antibody, TPNC 10, was directed to basilar crypt cell inclusions and was specific for the small bowel and possible progenitor cells. Another antibody, TPNC 30, was directed to the microvilli of the brush border. Finally, three antibodies, TPNC 50, 51 and 52 reacted with epithelial cell membranes. These three antibodies reacted with intestinal epithelial cell membranes but also cross-reacted with hepatocyte cytoplasm. The availability of intestinal specific monoclonal reagents will be of significant interest in studies of normal and abnormal intestinal physiology.

Original languageEnglish (US)
Pages (from-to)19-32
Number of pages14
JournalHybridoma
Volume7
Issue number1
StatePublished - 1988

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Monoclonal Antibodies
Antibodies
Epithelial Cells
Microvilli
Cell Membrane
Goblet Cells
Mucins
Cellular Structures
Hepatocytes
Cytoplasm
Stem Cells

ASJC Scopus subject areas

  • Genetics
  • Immunology

Cite this

Characteristics of gut specific monoclonal antibodies. / Prindiville, Thomas P; Gershwin, M. Eric.

In: Hybridoma, Vol. 7, No. 1, 1988, p. 19-32.

Research output: Contribution to journalArticle

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