Characteristics of cisternal cerebrospinal fluid associated with intracranial meningiomas in dogs: 56 Cases (1985-2004)

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Abstract

Objective - To determine CSF characteristics associated with intracranial meningiomas in dogs. Design - Retrospective case series. Animals - 56 dogs with intracranial meningiomas. Procedures - Medical records of dogs with a histopathologic diagnosis of intracranial meningioma, in which CSF analysis had been performed, were reviewed. Information concerning total nucleated cell counts (TNCCs) and differential nucleated cell counts, RBC counts, and total protein concentration in CSF; seizure history and glucocorticoid administration; and location of meningiomas was recorded. Results - TNCCs < 5 cells/μL were detected in 41 of 56 (73%) dogs; 5 of 56 (9%) dogs had TNCCs > 50 cells/μL. Analysis of CSF revealed predominantly neutrophilic pleocytosis in < 20% of dogs. There was a significant association between meningioma location (caudal portion of the cranial fossa or middle and rostral portion of the cranial fossae) and increased TNCCs (≥ 5 cells/μL). Conclusions and Clinical Relevance - Results were significantly different from those routinely reported in the veterinary literature. Neutrophilic pleocytosis, especially with TNCCs > 50 cells/μL, was not typical in CSF samples from dogs with intracranial meningiomas. Neutrophilic pleocytosis may not be detected in CSF samples from dogs with meningiomas located within the middle or rostral portion of the cranial fossae.

Original languageEnglish (US)
Pages (from-to)564-567
Number of pages4
JournalJournal of the American Veterinary Medical Association
Volume228
Issue number4
DOIs
StatePublished - Feb 15 2006

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Meningioma
cerebrospinal fluid
Cerebrospinal Fluid
Dogs
dogs
Cell Count
Leukocytosis
cells
seizures
glucocorticoids
Glucocorticoids
Medical Records
Seizures
sampling
history
animals
proteins
Proteins

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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title = "Characteristics of cisternal cerebrospinal fluid associated with intracranial meningiomas in dogs: 56 Cases (1985-2004)",
abstract = "Objective - To determine CSF characteristics associated with intracranial meningiomas in dogs. Design - Retrospective case series. Animals - 56 dogs with intracranial meningiomas. Procedures - Medical records of dogs with a histopathologic diagnosis of intracranial meningioma, in which CSF analysis had been performed, were reviewed. Information concerning total nucleated cell counts (TNCCs) and differential nucleated cell counts, RBC counts, and total protein concentration in CSF; seizure history and glucocorticoid administration; and location of meningiomas was recorded. Results - TNCCs < 5 cells/μL were detected in 41 of 56 (73{\%}) dogs; 5 of 56 (9{\%}) dogs had TNCCs > 50 cells/μL. Analysis of CSF revealed predominantly neutrophilic pleocytosis in < 20{\%} of dogs. There was a significant association between meningioma location (caudal portion of the cranial fossa or middle and rostral portion of the cranial fossae) and increased TNCCs (≥ 5 cells/μL). Conclusions and Clinical Relevance - Results were significantly different from those routinely reported in the veterinary literature. Neutrophilic pleocytosis, especially with TNCCs > 50 cells/μL, was not typical in CSF samples from dogs with intracranial meningiomas. Neutrophilic pleocytosis may not be detected in CSF samples from dogs with meningiomas located within the middle or rostral portion of the cranial fossae.",
author = "Dickinson, {Peter J} and Beverly Sturges and Kass, {Philip H} and Lecouteur, {Richard A}",
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T1 - Characteristics of cisternal cerebrospinal fluid associated with intracranial meningiomas in dogs

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AU - Sturges, Beverly

AU - Kass, Philip H

AU - Lecouteur, Richard A

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N2 - Objective - To determine CSF characteristics associated with intracranial meningiomas in dogs. Design - Retrospective case series. Animals - 56 dogs with intracranial meningiomas. Procedures - Medical records of dogs with a histopathologic diagnosis of intracranial meningioma, in which CSF analysis had been performed, were reviewed. Information concerning total nucleated cell counts (TNCCs) and differential nucleated cell counts, RBC counts, and total protein concentration in CSF; seizure history and glucocorticoid administration; and location of meningiomas was recorded. Results - TNCCs < 5 cells/μL were detected in 41 of 56 (73%) dogs; 5 of 56 (9%) dogs had TNCCs > 50 cells/μL. Analysis of CSF revealed predominantly neutrophilic pleocytosis in < 20% of dogs. There was a significant association between meningioma location (caudal portion of the cranial fossa or middle and rostral portion of the cranial fossae) and increased TNCCs (≥ 5 cells/μL). Conclusions and Clinical Relevance - Results were significantly different from those routinely reported in the veterinary literature. Neutrophilic pleocytosis, especially with TNCCs > 50 cells/μL, was not typical in CSF samples from dogs with intracranial meningiomas. Neutrophilic pleocytosis may not be detected in CSF samples from dogs with meningiomas located within the middle or rostral portion of the cranial fossae.

AB - Objective - To determine CSF characteristics associated with intracranial meningiomas in dogs. Design - Retrospective case series. Animals - 56 dogs with intracranial meningiomas. Procedures - Medical records of dogs with a histopathologic diagnosis of intracranial meningioma, in which CSF analysis had been performed, were reviewed. Information concerning total nucleated cell counts (TNCCs) and differential nucleated cell counts, RBC counts, and total protein concentration in CSF; seizure history and glucocorticoid administration; and location of meningiomas was recorded. Results - TNCCs < 5 cells/μL were detected in 41 of 56 (73%) dogs; 5 of 56 (9%) dogs had TNCCs > 50 cells/μL. Analysis of CSF revealed predominantly neutrophilic pleocytosis in < 20% of dogs. There was a significant association between meningioma location (caudal portion of the cranial fossa or middle and rostral portion of the cranial fossae) and increased TNCCs (≥ 5 cells/μL). Conclusions and Clinical Relevance - Results were significantly different from those routinely reported in the veterinary literature. Neutrophilic pleocytosis, especially with TNCCs > 50 cells/μL, was not typical in CSF samples from dogs with intracranial meningiomas. Neutrophilic pleocytosis may not be detected in CSF samples from dogs with meningiomas located within the middle or rostral portion of the cranial fossae.

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