Characteristics of CA1 neurons recorded intracellularly in the hippocampal in vitro slice preparation

Philip A Schwartzkroin

doi:10.1016/0006-8993(75)90817-3

Characteristics of CA1 neurons recorded intracellularly in the hippocampal in vitro slice preparation

Philip A Schwartzkroin

Research output: Contribution to journal › Article › peer-review

393 Scopus citations

Abstract

Intracellular recordings were made from CA1 pyramidal cells in the hippocampal in vitro slice preparation. Neurons displayed characteristics previously described for the intact preparation including: EPSPs, IPSPs, depolarizing after-potentials, bursting, frequency potentiation, double pulse facilitation, and probable dendritic spiking. Cells could be discharged when orthodromic or antidromic pathways were stimulated, with injection of a depolarizing current pulse, and from iontophoresis of glutamic acid. The apparently normal behavior of the neurons makes the isolated hippocampal slice a promising cortical preparation.

Original language	English (US)
Pages (from-to)	423-436
Number of pages	14
Journal	Brain Research
Volume	85
Issue number	3
DOIs	https://doi.org/10.1016/0006-8993(75)90817-3
State	Published - Mar 7 1975
Externally published	Yes

ASJC Scopus subject areas

Developmental Biology
Molecular Biology
Clinical Neurology
Neuroscience(all)

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AB - Intracellular recordings were made from CA1 pyramidal cells in the hippocampal in vitro slice preparation. Neurons displayed characteristics previously described for the intact preparation including: EPSPs, IPSPs, depolarizing after-potentials, bursting, frequency potentiation, double pulse facilitation, and probable dendritic spiking. Cells could be discharged when orthodromic or antidromic pathways were stimulated, with injection of a depolarizing current pulse, and from iontophoresis of glutamic acid. The apparently normal behavior of the neurons makes the isolated hippocampal slice a promising cortical preparation.

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Characteristics of CA1 neurons recorded intracellularly in the hippocampal in vitro slice preparation

Abstract

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