Characteristics of CA1 neurons recorded intracellularly in the hippocampal in vitro slice preparation

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390 Scopus citations

Abstract

Intracellular recordings were made from CA1 pyramidal cells in the hippocampal in vitro slice preparation. Neurons displayed characteristics previously described for the intact preparation including: EPSPs, IPSPs, depolarizing after-potentials, bursting, frequency potentiation, double pulse facilitation, and probable dendritic spiking. Cells could be discharged when orthodromic or antidromic pathways were stimulated, with injection of a depolarizing current pulse, and from iontophoresis of glutamic acid. The apparently normal behavior of the neurons makes the isolated hippocampal slice a promising cortical preparation.

Original languageEnglish (US)
Pages (from-to)423-436
Number of pages14
JournalBrain Research
Volume85
Issue number3
DOIs
StatePublished - Mar 7 1975
Externally publishedYes

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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