Characteristic transformation of blood transcriptome in Alzheimer's disease

Guangchun Han, Jiajia Wang, Fan Zeng, Xuemei Feng, Jun Yu, Hong Yuan Cao, Xu Yi, Huadong Zhou, Lee-Way Jin, Yong Duan, Yan Jiang Wang, Hongxing Lei

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Blood transcriptome has emerged as a potential resource for the discovery of biomarkers for Alzheimer's disease (AD). However, the validity of blood transcriptome in the early diagnosis of AD has yet to be extensively tested. In this work, we analyzed published data on AD blood transcriptome and revealed the characteristic perturbation of cellular functional units, including upregulation of environmental responses (immune response, survival/death signaling, and cellular recycling) and down-regulation of core metabolism (energy metabolism and translation/splicing). This characteristic perturbation was unique to AD based on the comparison with blood transcriptome from other neurological disorders and complex diseases. More importantly, similar perturbation was observed in both AD and mild cognitive impairment (MCI) groups. This perturbation pattern was further validated in our independent microarray experiment in a small Chinese cohort. In addition, the potential effect of aging and lifestyle on blood transcriptome was discussed. Based on the analyses, we propose that the transformation of the blood transcriptome in AD is an integrated part of the disease mechanism and has potential to serve as a reliable biomarker for assisting the early diagnosis as well as monitoring purpose. Therefore, more independent studies on blood transcriptome of AD and MCI with larger sample size are warranted.

Original languageEnglish (US)
Pages (from-to)373-386
Number of pages14
JournalJournal of Alzheimer's Disease
Volume35
Issue number2
DOIs
StatePublished - 2013

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Keywords

  • Blood
  • energy metabolism
  • immune response
  • microarray
  • ribosome

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Han, G., Wang, J., Zeng, F., Feng, X., Yu, J., Cao, H. Y., Yi, X., Zhou, H., Jin, L-W., Duan, Y., Wang, Y. J., & Lei, H. (2013). Characteristic transformation of blood transcriptome in Alzheimer's disease. Journal of Alzheimer's Disease, 35(2), 373-386. https://doi.org/10.3233/JAD-121963