Chapter 18 Computational Approaches to Finding and Analyzing cis-Regulatory Elements

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

The transcription of almost all developmental genes is driven by tissue- and time-specific regulatory elements. These transcriptional regulatory elements lie in the genomic DNA proximal to the gene, and hence are cis-regulatory (as opposed to trans-regulatory elements like transcription factor genes). Over the past three decades, a number of techniques have been applied to the problem of finding and characterizing these regulatory elements. In this chapter, I discuss some computational approaches that have been particularly useful in identifying developmental cis-regulatory regions, and provide a tutorial on how to apply these approaches to the study of chick development.

Original languageEnglish (US)
Title of host publicationAvian Embryology, 2nd Edition
Pages337-365
Number of pages29
DOIs
StatePublished - May 19 2008
Externally publishedYes

Publication series

NameMethods in Cell Biology
Volume87
ISSN (Print)0091-679X

ASJC Scopus subject areas

  • Cell Biology

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    Brown, C. (2008). Chapter 18 Computational Approaches to Finding and Analyzing cis-Regulatory Elements. In Avian Embryology, 2nd Edition (pp. 337-365). (Methods in Cell Biology; Vol. 87). https://doi.org/10.1016/S0091-679X(08)00218-5