Chapter 11 The role of GTP in protein targeting to the endoplasmic reticulum

Stephen C. Ogg, Jodi M. Nunnari, Joshua D. Miller, Peter Walter

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Abstract. GTP has been shown to be required for the translocation of nascent secretory and membrane proteins into the lumen of the endoplasmic reticulum (ER). To date, three components known to be involved in protein translocation, the 54 kDa sub-unit of SRP (SRP54) and both the alpha and the beta subunits of the SRP receptor (SRa and SRβ) have been shown to be GTPases. Here, we briefly review what is known about the role of GTP in protein translocation, and we present a speculative model that incorporates these findings.

Original languageEnglish (US)
Pages (from-to)129-136
Number of pages8
JournalNew Comprehensive Biochemistry
Volume22
Issue numberC
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Protein Transport
Guanosine Triphosphate
Endoplasmic Reticulum
GTP Phosphohydrolases
Membrane Proteins
Proteins
signal peptide receptor

ASJC Scopus subject areas

  • Biochemistry

Cite this

Chapter 11 The role of GTP in protein targeting to the endoplasmic reticulum. / Ogg, Stephen C.; Nunnari, Jodi M.; Miller, Joshua D.; Walter, Peter.

In: New Comprehensive Biochemistry, Vol. 22, No. C, 1992, p. 129-136.

Research output: Contribution to journalArticle

Ogg, Stephen C. ; Nunnari, Jodi M. ; Miller, Joshua D. ; Walter, Peter. / Chapter 11 The role of GTP in protein targeting to the endoplasmic reticulum. In: New Comprehensive Biochemistry. 1992 ; Vol. 22, No. C. pp. 129-136.
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