Abstract
Our current understanding of eukaryotic protein synthesis has emerged from many years of biochemical, genetic and biophysical approaches. Significant insight into the molecular details of the mechanism has been obtained, although there are clearly many aspects of the process that remain to be resolved. Importantly, our understanding of the mechanism has identified a number of key stages in the pathway that contribute to the regulation of general and gene-specific translation. Not surprisingly, translational control is now widely accepted to play a role in aspects of cell stress, growth, development, synaptic function, aging, and disease. This chapter reviews the mechanism of eukaryotic protein synthesis and its relevance to translational control.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-51 |
| Number of pages | 51 |
| Journal | Progress in Molecular Biology and Translational Science |
| Volume | 90 |
| Issue number | C |
| DOIs | |
| State | Published - 2009 |
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Keywords
- Initiation factor
- mRNA
- Peptide bond
- Phosphorylation
- Ribosome
- Scanning
ASJC Scopus subject areas
- Molecular Biology
- Molecular Medicine
Cite this
Chapter 1 The Molecular Basis of Translational Control. / Fraser, Christopher S.
In: Progress in Molecular Biology and Translational Science, Vol. 90, No. C, 2009, p. 1-51.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chapter 1 The Molecular Basis of Translational Control
AU - Fraser, Christopher S.
PY - 2009
Y1 - 2009
N2 - Our current understanding of eukaryotic protein synthesis has emerged from many years of biochemical, genetic and biophysical approaches. Significant insight into the molecular details of the mechanism has been obtained, although there are clearly many aspects of the process that remain to be resolved. Importantly, our understanding of the mechanism has identified a number of key stages in the pathway that contribute to the regulation of general and gene-specific translation. Not surprisingly, translational control is now widely accepted to play a role in aspects of cell stress, growth, development, synaptic function, aging, and disease. This chapter reviews the mechanism of eukaryotic protein synthesis and its relevance to translational control.
AB - Our current understanding of eukaryotic protein synthesis has emerged from many years of biochemical, genetic and biophysical approaches. Significant insight into the molecular details of the mechanism has been obtained, although there are clearly many aspects of the process that remain to be resolved. Importantly, our understanding of the mechanism has identified a number of key stages in the pathway that contribute to the regulation of general and gene-specific translation. Not surprisingly, translational control is now widely accepted to play a role in aspects of cell stress, growth, development, synaptic function, aging, and disease. This chapter reviews the mechanism of eukaryotic protein synthesis and its relevance to translational control.
KW - Initiation factor
KW - mRNA
KW - Peptide bond
KW - Phosphorylation
KW - Ribosome
KW - Scanning
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U2 - 10.1016/S1877-1173(09)90001-1
DO - 10.1016/S1877-1173(09)90001-1
M3 - Article
VL - 90
SP - 1
EP - 51
JO - Progress in Molecular Biology and Translational Science
JF - Progress in Molecular Biology and Translational Science
SN - 1877-1173
IS - C
ER -