Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma

Megan L. Ludwig, Andrew C. Birkeland, Rebecca Hoesli, Paul Swiecicki, Matthew E. Spector, J. Chad Brenner

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

Laryngeal squamous cell carcinoma (LSCC) remains a highly morbid and fatal disease. Historically, it has been a model example for organ preservation and treatment stratification paradigms. Unfortunately, survival for LSCC has stagnated over the past few decades. As the era of next-generation sequencing and personalized treatment for cancer approaches, LSCC may be an ideal disease for consideration of further treatment stratification and personalization. Here, we will discuss the important history of LSCC as a model system for organ preservation, unique and potentially targetable genetic signatures of LSCC, and methods for bringing stratified, personalized treatment strategies to the 21st century.

Original languageEnglish (US)
Pages (from-to)87-100
Number of pages14
JournalCancer Biology and Medicine
Volume13
Issue number1
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

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Keywords

  • Genetics
  • Head and neck cancer
  • Laryngeal squamous cell carcinoma
  • Personalized medicine
  • Targeted therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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