Changing perspectives in cleft lip and palate: From acrylic to allele

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cleft lip and palate deformities are the most common congenital abnormalities of the head and neck. Advancements in the various multidisciplinary fields involved in cleft management have substantially improved functional and aesthetic outcomes. The legitimacy of such controversial topics as gingivoperiosteoplasty, primary rhinoplasty, and presurgical nasoalveolar molding is heavily contested. Bone morphogenetic protein and other recombinant growth factors may play important roles in future cleft care. As the candidate alleles that contribute to cleft lip and palate are further elucidated, the complex interplay of environmental influence and genetic predisposition is emphasized. Translational research from fields such as fetal wound healing, tissue engineering, and gene therapy may have clinical applications as cleft care continues to evolve.

Original languageEnglish (US)
Pages (from-to)395-400
Number of pages6
JournalArchives of Facial Plastic Surgery
Volume10
Issue number6
DOIs
StatePublished - Nov 2008

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Cleft Lip
Cleft Palate
Alleles
Illegitimacy
Rhinoplasty
Bone Morphogenetic Proteins
Translational Medical Research
Tissue Engineering
Genetic Predisposition to Disease
Cell- and Tissue-Based Therapy
Esthetics
Genetic Therapy
Wound Healing
Intercellular Signaling Peptides and Proteins
Neck
Head

ASJC Scopus subject areas

  • Surgery

Cite this

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AB - Cleft lip and palate deformities are the most common congenital abnormalities of the head and neck. Advancements in the various multidisciplinary fields involved in cleft management have substantially improved functional and aesthetic outcomes. The legitimacy of such controversial topics as gingivoperiosteoplasty, primary rhinoplasty, and presurgical nasoalveolar molding is heavily contested. Bone morphogenetic protein and other recombinant growth factors may play important roles in future cleft care. As the candidate alleles that contribute to cleft lip and palate are further elucidated, the complex interplay of environmental influence and genetic predisposition is emphasized. Translational research from fields such as fetal wound healing, tissue engineering, and gene therapy may have clinical applications as cleft care continues to evolve.

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