Abstract
Prostaglandins are known to be involved in bone metabolism as evidenced by the ability of PGE2 to induce bone resorption. It was, therefore, of interest to determine if there was an association of specific prostaglandin metabolites with the various stages of developing bone by utilizing the matrix-induced endochondral bone formation system. During mesenchymal cell proliferation a peak of endogenous thromboxane B2 was detected. In the subsequent stages of chondrogenesis and chondrolysis PGF2α was in high concentration, whereas during bone formation PGE2, 6-Keto-PGF1α and thromboxane B2 were elevated. These changes in the peak levels of the various prostaglandin metabolites may reflect differences in the cell populations and function associated with various stages of endochondral bone formation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 746-750 |
| Number of pages | 5 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 117 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 28 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Changes in tissue concentration of prostaglandins during endochondral bone differentiation. / Wientroub, S.; Wahl, L. M.; Feuerstein, N.; Winter, C. C.; Reddi, A Hari.
In: Biochemical and Biophysical Research Communications, Vol. 117, No. 3, 28.12.1983, p. 746-750.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changes in tissue concentration of prostaglandins during endochondral bone differentiation
AU - Wientroub, S.
AU - Wahl, L. M.
AU - Feuerstein, N.
AU - Winter, C. C.
AU - Reddi, A Hari
PY - 1983/12/28
Y1 - 1983/12/28
N2 - Prostaglandins are known to be involved in bone metabolism as evidenced by the ability of PGE2 to induce bone resorption. It was, therefore, of interest to determine if there was an association of specific prostaglandin metabolites with the various stages of developing bone by utilizing the matrix-induced endochondral bone formation system. During mesenchymal cell proliferation a peak of endogenous thromboxane B2 was detected. In the subsequent stages of chondrogenesis and chondrolysis PGF2α was in high concentration, whereas during bone formation PGE2, 6-Keto-PGF1α and thromboxane B2 were elevated. These changes in the peak levels of the various prostaglandin metabolites may reflect differences in the cell populations and function associated with various stages of endochondral bone formation.
AB - Prostaglandins are known to be involved in bone metabolism as evidenced by the ability of PGE2 to induce bone resorption. It was, therefore, of interest to determine if there was an association of specific prostaglandin metabolites with the various stages of developing bone by utilizing the matrix-induced endochondral bone formation system. During mesenchymal cell proliferation a peak of endogenous thromboxane B2 was detected. In the subsequent stages of chondrogenesis and chondrolysis PGF2α was in high concentration, whereas during bone formation PGE2, 6-Keto-PGF1α and thromboxane B2 were elevated. These changes in the peak levels of the various prostaglandin metabolites may reflect differences in the cell populations and function associated with various stages of endochondral bone formation.
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U2 - 10.1016/0006-291X(83)91660-1
DO - 10.1016/0006-291X(83)91660-1
M3 - Article
VL - 117
SP - 746
EP - 750
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -