Changes in tissue concentration of prostaglandins during endochondral bone differentiation

S. Wientroub, L. M. Wahl, N. Feuerstein, C. C. Winter, A Hari Reddi

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Prostaglandins are known to be involved in bone metabolism as evidenced by the ability of PGE2 to induce bone resorption. It was, therefore, of interest to determine if there was an association of specific prostaglandin metabolites with the various stages of developing bone by utilizing the matrix-induced endochondral bone formation system. During mesenchymal cell proliferation a peak of endogenous thromboxane B2 was detected. In the subsequent stages of chondrogenesis and chondrolysis PGF2α was in high concentration, whereas during bone formation PGE2, 6-Keto-PGF1α and thromboxane B2 were elevated. These changes in the peak levels of the various prostaglandin metabolites may reflect differences in the cell populations and function associated with various stages of endochondral bone formation.

Original languageEnglish (US)
Pages (from-to)746-750
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume117
Issue number3
DOIs
StatePublished - Dec 28 1983
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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