Changes in the testicular morphology of chinchillas (Chinchilla lanigera) implanted with zeranol

Francisco R Carvallo chaigneau, Carolina A. Santibañez, Tamara A. Tadich

Research output: Contribution to journalArticle

Abstract

Zeranol is a semi-synthetic non-steroidal product used by chinchilla breeders to improve fur quality. The aim of this study was to assess the potential deleterious effects of zeranol in chinchilla at testicular level. For this purpose, 27 chinchillas received 6 mg of zeranol and 9 untreated chinchillas were used as control. Testicles were recovered after routine sacrifice, and the weight, length, width and testicular perimeter were recorded. Individual information regarding sex, age, weight at birth, at weaning and at sacrifice of chinchilla was obtained from the breeders records. The testes were processed for routine histological evaluation. Treated animals evidenced a significant reduction in testicular weight, length, width and perimeter. Histological findings included a reduction in the tubular lumen, loss of epithelium and disappearance of spermatozoids in the seminiferous tubules. Data suggests that zeranol produces toxic effects on the testis including degenerative damage in germ cells and Leydig cells, thus affecting spermatogenesis.

Original languageEnglish (US)
Pages (from-to)103-105
Number of pages3
JournalPakistan Veterinary Journal
Volume35
Issue number1
StatePublished - 2015

Fingerprint

Zeranol
zeranol
Chinchilla
Testis
testes
Weights and Measures
Seminiferous Tubules
Leydig cells
seminiferous tubules
Leydig Cells
Poisons
Spermatogenesis
spermatogenesis
Weaning
Birth Weight
Germ Cells
fur
germ cells
weaning
epithelium

Keywords

  • Chinchilla
  • Estrogen
  • Testicular degeneration
  • Zeranol

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Changes in the testicular morphology of chinchillas (Chinchilla lanigera) implanted with zeranol. / Carvallo chaigneau, Francisco R; Santibañez, Carolina A.; Tadich, Tamara A.

In: Pakistan Veterinary Journal, Vol. 35, No. 1, 2015, p. 103-105.

Research output: Contribution to journalArticle

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