Changes in the morphometric parameters of neuroblastoma cells cultured in a high pH medium

N. Kh Pogorelaya, Alla F Fomina

Research output: Contribution to journalArticle

Abstract

The development of a population of morphologically differentiated mouse neuroblastoma cells was investigated during culture in a medium with a pH of 8.0-8.2. The original population split into two subpopulations - one of proliferating and the other differentiating cells - on the third day of culture in modified medium. Changes in the morphometric parameters of cells differentiating with time was investigated in vivo. A significant correlation between somatic dimensions and neurite length was found in differentiating cells. This implies that degree of morphological differentiation may be determined by size of the soma when using this technique for inducing differentiation. The patterns noted may serve for further research into morphofunctional changes produced by induced differentiation of neuroblastoma cells.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalNeurophysiology
Volume20
Issue number2
DOIs
StatePublished - Mar 1988
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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