Abstract
Background: Studies of the impact of Roux-en-Y gastric bypass (RYGB) on renal function have shown mixed results. We constructed this prospective repeated-measures controlled study to characterize this response and identify the best method of gauging renal function in this setting. Methods: Clinical data, serum creatinine (SC), and 24-h urine were collected 1 week before and 6 months following RYGB. Glomerular filtration rate (GFR) was calculated utilizing the Modification of Diet in Renal Disease formula. Creatinine clearance (CCL) was measured as a 24-h collection (24CCL) and calculated by the Cockcroft-Gault (CG) formula. Results: The study population of 37 patients (81% women) had a mean age of 47±11 years, had mean BMI of 47.6±6.3 kg/m 2, and achieved a mean % excess weight loss (EWL) of 60.9±17.1%. SC decreased from 0.83±0.21 mg/dl to 0.72±0.16 mg/dl (p<0.001) and mean GFR improved from 91.6±29.7 ml/min/1.73 m2 to 104.9±23.5 ml/min/1.73 m2 (p<0.01). Preoperatively, CG significantly overestimated CCL when compared with 24CCL (197.1±88.2 ml/min vs. 136.5±53.0 ml/min, p<0.001). In all patients, improvement in 24CCL correlated with EWL (r=0.32) and %EWL (r=0.16), and significantly correlated with decrease in BMI (r=0.51, p<0.005). In hypertensive patients, improvement in 24CCL significantly correlated with EWL (r=0.43, p<0.05), %EWL (r=0.40, p<0.05), and decrease in BMI (r=0.60, p<0.001) and was negatively correlated with age (r=-0.45, p<0.05). Conclusions: This study demonstrates that renal function improves following RYGB and is best identified by change in GFR. Improvement in 24CCL is correlated with the EWL success of the patient, especially hypertensive patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1055-1059 |
| Number of pages | 5 |
| Journal | Obesity Surgery |
| Volume | 22 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2012 |
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Keywords
- Diabetes
- Hypertension
- Morbid obesity
- Renal function
- Roux-en-Y gastric bypass
ASJC Scopus subject areas
- Surgery
- Endocrinology, Diabetes and Metabolism
- Nutrition and Dietetics
Cite this
Changes in renal function following Roux-en-Y gastric bypass : A prospective study. / Getty, Jorge L Zelada; Hamdallah, Isam N.; Shamseddeen, Hazem; Wu, Jennifer; Low, Roger; Craig, Jacqueline; Ali, Mohamed R.
In: Obesity Surgery, Vol. 22, No. 7, 07.2012, p. 1055-1059.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changes in renal function following Roux-en-Y gastric bypass
T2 - A prospective study
AU - Getty, Jorge L Zelada
AU - Hamdallah, Isam N.
AU - Shamseddeen, Hazem
AU - Wu, Jennifer
AU - Low, Roger
AU - Craig, Jacqueline
AU - Ali, Mohamed R
PY - 2012/7
Y1 - 2012/7
N2 - Background: Studies of the impact of Roux-en-Y gastric bypass (RYGB) on renal function have shown mixed results. We constructed this prospective repeated-measures controlled study to characterize this response and identify the best method of gauging renal function in this setting. Methods: Clinical data, serum creatinine (SC), and 24-h urine were collected 1 week before and 6 months following RYGB. Glomerular filtration rate (GFR) was calculated utilizing the Modification of Diet in Renal Disease formula. Creatinine clearance (CCL) was measured as a 24-h collection (24CCL) and calculated by the Cockcroft-Gault (CG) formula. Results: The study population of 37 patients (81% women) had a mean age of 47±11 years, had mean BMI of 47.6±6.3 kg/m 2, and achieved a mean % excess weight loss (EWL) of 60.9±17.1%. SC decreased from 0.83±0.21 mg/dl to 0.72±0.16 mg/dl (p<0.001) and mean GFR improved from 91.6±29.7 ml/min/1.73 m2 to 104.9±23.5 ml/min/1.73 m2 (p<0.01). Preoperatively, CG significantly overestimated CCL when compared with 24CCL (197.1±88.2 ml/min vs. 136.5±53.0 ml/min, p<0.001). In all patients, improvement in 24CCL correlated with EWL (r=0.32) and %EWL (r=0.16), and significantly correlated with decrease in BMI (r=0.51, p<0.005). In hypertensive patients, improvement in 24CCL significantly correlated with EWL (r=0.43, p<0.05), %EWL (r=0.40, p<0.05), and decrease in BMI (r=0.60, p<0.001) and was negatively correlated with age (r=-0.45, p<0.05). Conclusions: This study demonstrates that renal function improves following RYGB and is best identified by change in GFR. Improvement in 24CCL is correlated with the EWL success of the patient, especially hypertensive patients.
AB - Background: Studies of the impact of Roux-en-Y gastric bypass (RYGB) on renal function have shown mixed results. We constructed this prospective repeated-measures controlled study to characterize this response and identify the best method of gauging renal function in this setting. Methods: Clinical data, serum creatinine (SC), and 24-h urine were collected 1 week before and 6 months following RYGB. Glomerular filtration rate (GFR) was calculated utilizing the Modification of Diet in Renal Disease formula. Creatinine clearance (CCL) was measured as a 24-h collection (24CCL) and calculated by the Cockcroft-Gault (CG) formula. Results: The study population of 37 patients (81% women) had a mean age of 47±11 years, had mean BMI of 47.6±6.3 kg/m 2, and achieved a mean % excess weight loss (EWL) of 60.9±17.1%. SC decreased from 0.83±0.21 mg/dl to 0.72±0.16 mg/dl (p<0.001) and mean GFR improved from 91.6±29.7 ml/min/1.73 m2 to 104.9±23.5 ml/min/1.73 m2 (p<0.01). Preoperatively, CG significantly overestimated CCL when compared with 24CCL (197.1±88.2 ml/min vs. 136.5±53.0 ml/min, p<0.001). In all patients, improvement in 24CCL correlated with EWL (r=0.32) and %EWL (r=0.16), and significantly correlated with decrease in BMI (r=0.51, p<0.005). In hypertensive patients, improvement in 24CCL significantly correlated with EWL (r=0.43, p<0.05), %EWL (r=0.40, p<0.05), and decrease in BMI (r=0.60, p<0.001) and was negatively correlated with age (r=-0.45, p<0.05). Conclusions: This study demonstrates that renal function improves following RYGB and is best identified by change in GFR. Improvement in 24CCL is correlated with the EWL success of the patient, especially hypertensive patients.
KW - Diabetes
KW - Hypertension
KW - Morbid obesity
KW - Renal function
KW - Roux-en-Y gastric bypass
UR - http://www.scopus.com/inward/record.url?scp=84862829255&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862829255&partnerID=8YFLogxK
U2 - 10.1007/s11695-012-0617-0
DO - 10.1007/s11695-012-0617-0
M3 - Article
C2 - 22318447
AN - SCOPUS:84862829255
VL - 22
SP - 1055
EP - 1059
JO - Obesity Surgery
JF - Obesity Surgery
SN - 0960-8923
IS - 7
ER -