Changes in regional brain acetylcholine content in rats following unilateral and bilateral brainstem lesions

T. Yamamoto, Bruce G Lyeth, C. E. Dixon, S. E. Robinson, L. W. Jenkins, H. F. Young, H. H. Stonnington, R. L. Hayes

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Previous research (Adametz, 1959) has shown that two-step bilateral lesions of the reticular formation in cats produce minimal behavioral disruption compared to one-step bilateral lesions, which produce profound behavioral suppression. We systematically examined alterations in forebrain acetylcholine (ACh) content and neurologic tolerance to one-step and two-step bilateral and unilateral lesions of the pontomesencephalic reticular formation (PMRF) in rats. One-step and two-step bilateral lesions separated by 1 or 5 days produced irreversible bilateral motor dysfunction. Survival after lesioning was 10%, 20%, and 0%, respectively. Unilateral lesion or two-step bilateral lesions separated by 15 or 30 days produced transient (less than 3 days) contralateral motor dysfunction. Survival after lesioning was 90%, 90%, and 100%, respectively. Within 25 h after one-step bilateral lesions, ACh content was significantly decreased bilaterally in thalamus, frontal cortex, amygdala, hippocampus, and basal forebrain. Within 5 days after unilateral lesioning, ACh content was significantly decreased ipsilaterally in the thalamus, amygdala, and hippocampus and has returned to control values by day 10 in the thalamus and hippocampus. The increased neurologic tolerance and recovery of ACh content in two-step bilateral PMRF lesions demonstrate important functional and neurochemical plasticity to brain injury. Although not directly addressing mechanisms of neural plasticity, this research examined possible associations between neurologic tolerance of PMRF lesions and neurochemical markers of forebrain ACh activity.

Original languageEnglish (US)
Pages (from-to)69-79
Number of pages11
JournalJournal of Neurotrauma
Volume5
Issue number1
StatePublished - 1988
Externally publishedYes

Fingerprint

Reticular Formation
Brain Stem
Acetylcholine
Thalamus
Nervous System
Brain
Hippocampus
Prosencephalon
Amygdala
Neuronal Plasticity
Frontal Lobe
Research
Brain Injuries
Cats

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Yamamoto, T., Lyeth, B. G., Dixon, C. E., Robinson, S. E., Jenkins, L. W., Young, H. F., ... Hayes, R. L. (1988). Changes in regional brain acetylcholine content in rats following unilateral and bilateral brainstem lesions. Journal of Neurotrauma, 5(1), 69-79.

Changes in regional brain acetylcholine content in rats following unilateral and bilateral brainstem lesions. / Yamamoto, T.; Lyeth, Bruce G; Dixon, C. E.; Robinson, S. E.; Jenkins, L. W.; Young, H. F.; Stonnington, H. H.; Hayes, R. L.

In: Journal of Neurotrauma, Vol. 5, No. 1, 1988, p. 69-79.

Research output: Contribution to journalArticle

Yamamoto, T, Lyeth, BG, Dixon, CE, Robinson, SE, Jenkins, LW, Young, HF, Stonnington, HH & Hayes, RL 1988, 'Changes in regional brain acetylcholine content in rats following unilateral and bilateral brainstem lesions', Journal of Neurotrauma, vol. 5, no. 1, pp. 69-79.
Yamamoto, T. ; Lyeth, Bruce G ; Dixon, C. E. ; Robinson, S. E. ; Jenkins, L. W. ; Young, H. F. ; Stonnington, H. H. ; Hayes, R. L. / Changes in regional brain acetylcholine content in rats following unilateral and bilateral brainstem lesions. In: Journal of Neurotrauma. 1988 ; Vol. 5, No. 1. pp. 69-79.
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