Abstract
Background: Ghrelin is a body weight-regulating peptide produced and secreted primarily by the gastric mucosa. Helicobacter pylori infection impairs gastric ghrelin production, leading to a lower plasma ghrelin concentration. However, the effect of H. pylori eradication on plasma ghrelin levels and its relation to body weight change after H. pylori cure are still uncertain. We examined the association of plasma ghrelin levels with gastric ghrelin production and body weight change before and after H. pylori eradication. Methods: Plasma ghrelin concentrations, gastric ghrelin expression, and body weight were determined in a total of 134 consecutive individuals before and 12 weeks after successful H. pylori eradication. Gastric ghrelin expression was evaluated by determining mRNA expression levels and the number of ghrelin-producing cells in gastric mucosa biopsy specimens by real-time reverse transcriptase-polymerase chain reaction and immunohistochemistry, respectively. Results: Plasma ghrelin concentration increased in 50 patients and decreased in 84 patients after H. pylori eradication. After H. pylori cure, however, gastric preproghrelin mRNA expression was increased nearly fourfold (P < 0.0001), and the number of ghrelin-positive cells was increased or unchanged. In contrast, plasma ghrelin changes after H. pylori cure were inversely correlated with both body weight change (P < 0.0001) and initial plasma ghrelin levels (P < 0.0001). Conclusions: Changes in plasma ghrelin concentrations before and after H. pylori cure were inversely correlated with body weight change and initial plasma ghrelin levels but not with gastric ghrelin production in Japanese patients.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 954-961 |
| Number of pages | 8 |
| Journal | Journal of Gastroenterology |
| Volume | 41 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2006 |
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Keywords
- Body weight
- Gastric ghrelin
- Helicobacter pylori cure
- Plasma ghrelin
ASJC Scopus subject areas
- Gastroenterology
Cite this
Changes in plasma ghrelin levels, gastric ghrelin production, and body weight after Helicobacter pylori cure. / Osawa, Hiroyuki; Kita, Hiroto; Ohnishi, Hirohide; Nakazato, Masamitsu; Date, Yukari; Bowlus, Christopher; Ishino, Yumiko; Watanabe, Eiko; Shiiya, Tomomi; Ueno, Hiroaki; Hoshino, Hiroko; Satoh, Kiichi; Sugano, Kentaro.
In: Journal of Gastroenterology, Vol. 41, No. 10, 10.2006, p. 954-961.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changes in plasma ghrelin levels, gastric ghrelin production, and body weight after Helicobacter pylori cure
AU - Osawa, Hiroyuki
AU - Kita, Hiroto
AU - Ohnishi, Hirohide
AU - Nakazato, Masamitsu
AU - Date, Yukari
AU - Bowlus, Christopher
AU - Ishino, Yumiko
AU - Watanabe, Eiko
AU - Shiiya, Tomomi
AU - Ueno, Hiroaki
AU - Hoshino, Hiroko
AU - Satoh, Kiichi
AU - Sugano, Kentaro
PY - 2006/10
Y1 - 2006/10
N2 - Background: Ghrelin is a body weight-regulating peptide produced and secreted primarily by the gastric mucosa. Helicobacter pylori infection impairs gastric ghrelin production, leading to a lower plasma ghrelin concentration. However, the effect of H. pylori eradication on plasma ghrelin levels and its relation to body weight change after H. pylori cure are still uncertain. We examined the association of plasma ghrelin levels with gastric ghrelin production and body weight change before and after H. pylori eradication. Methods: Plasma ghrelin concentrations, gastric ghrelin expression, and body weight were determined in a total of 134 consecutive individuals before and 12 weeks after successful H. pylori eradication. Gastric ghrelin expression was evaluated by determining mRNA expression levels and the number of ghrelin-producing cells in gastric mucosa biopsy specimens by real-time reverse transcriptase-polymerase chain reaction and immunohistochemistry, respectively. Results: Plasma ghrelin concentration increased in 50 patients and decreased in 84 patients after H. pylori eradication. After H. pylori cure, however, gastric preproghrelin mRNA expression was increased nearly fourfold (P < 0.0001), and the number of ghrelin-positive cells was increased or unchanged. In contrast, plasma ghrelin changes after H. pylori cure were inversely correlated with both body weight change (P < 0.0001) and initial plasma ghrelin levels (P < 0.0001). Conclusions: Changes in plasma ghrelin concentrations before and after H. pylori cure were inversely correlated with body weight change and initial plasma ghrelin levels but not with gastric ghrelin production in Japanese patients.
AB - Background: Ghrelin is a body weight-regulating peptide produced and secreted primarily by the gastric mucosa. Helicobacter pylori infection impairs gastric ghrelin production, leading to a lower plasma ghrelin concentration. However, the effect of H. pylori eradication on plasma ghrelin levels and its relation to body weight change after H. pylori cure are still uncertain. We examined the association of plasma ghrelin levels with gastric ghrelin production and body weight change before and after H. pylori eradication. Methods: Plasma ghrelin concentrations, gastric ghrelin expression, and body weight were determined in a total of 134 consecutive individuals before and 12 weeks after successful H. pylori eradication. Gastric ghrelin expression was evaluated by determining mRNA expression levels and the number of ghrelin-producing cells in gastric mucosa biopsy specimens by real-time reverse transcriptase-polymerase chain reaction and immunohistochemistry, respectively. Results: Plasma ghrelin concentration increased in 50 patients and decreased in 84 patients after H. pylori eradication. After H. pylori cure, however, gastric preproghrelin mRNA expression was increased nearly fourfold (P < 0.0001), and the number of ghrelin-positive cells was increased or unchanged. In contrast, plasma ghrelin changes after H. pylori cure were inversely correlated with both body weight change (P < 0.0001) and initial plasma ghrelin levels (P < 0.0001). Conclusions: Changes in plasma ghrelin concentrations before and after H. pylori cure were inversely correlated with body weight change and initial plasma ghrelin levels but not with gastric ghrelin production in Japanese patients.
KW - Body weight
KW - Gastric ghrelin
KW - Helicobacter pylori cure
KW - Plasma ghrelin
UR - http://www.scopus.com/inward/record.url?scp=33750997571&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750997571&partnerID=8YFLogxK
U2 - 10.1007/s00535-006-1880-4
DO - 10.1007/s00535-006-1880-4
M3 - Article
VL - 41
SP - 954
EP - 961
JO - Journal of Gastroenterology
JF - Journal of Gastroenterology
SN - 0944-1174
IS - 10
ER -