Changes in ornithine decarboxylase activity during matrix-induced cartilage, bone and bone marrow differentiation

N. C. Rath, A Hari Reddi

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Subcutaneous transplantation of coarse powders of demineralized rat diaphyseal bone matrix into allogeneic recipients results in new bone formation. The changes in ornithine decarboxylase activity during such bone matrix-induced sequential differentiation of cartilage, bone and bone marrow were investigated. There was a peak in ornithine decarboxylase activity on day 3 corresponding to the appearance of fibroblasts in close contiguity to the bone matrix. This was followed by another peak of enzyme activity on day 8 which was correlated with the onset of proliferation of presumptive osteoblasts and vascular endothelial cells. The peak of ornithine decarboxylase activity on day 3 appears to be a demineralized bone matrix-specific event. Induction of ornithine decarboxylase activity represents one of the early responses to implanted bone matrix.

Original languageEnglish (US)
Pages (from-to)106-113
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume81
Issue number1
DOIs
StatePublished - Mar 15 1978
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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