Abstract
Subcutaneous transplantation of coarse powders of demineralized rat diaphyseal bone matrix into allogeneic recipients results in new bone formation. The changes in ornithine decarboxylase activity during such bone matrix-induced sequential differentiation of cartilage, bone and bone marrow were investigated. There was a peak in ornithine decarboxylase activity on day 3 corresponding to the appearance of fibroblasts in close contiguity to the bone matrix. This was followed by another peak of enzyme activity on day 8 which was correlated with the onset of proliferation of presumptive osteoblasts and vascular endothelial cells. The peak of ornithine decarboxylase activity on day 3 appears to be a demineralized bone matrix-specific event. Induction of ornithine decarboxylase activity represents one of the early responses to implanted bone matrix.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 106-113 |
| Number of pages | 8 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 81 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 15 1978 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Changes in ornithine decarboxylase activity during matrix-induced cartilage, bone and bone marrow differentiation. / Rath, N. C.; Reddi, A Hari.
In: Biochemical and Biophysical Research Communications, Vol. 81, No. 1, 15.03.1978, p. 106-113.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changes in ornithine decarboxylase activity during matrix-induced cartilage, bone and bone marrow differentiation
AU - Rath, N. C.
AU - Reddi, A Hari
PY - 1978/3/15
Y1 - 1978/3/15
N2 - Subcutaneous transplantation of coarse powders of demineralized rat diaphyseal bone matrix into allogeneic recipients results in new bone formation. The changes in ornithine decarboxylase activity during such bone matrix-induced sequential differentiation of cartilage, bone and bone marrow were investigated. There was a peak in ornithine decarboxylase activity on day 3 corresponding to the appearance of fibroblasts in close contiguity to the bone matrix. This was followed by another peak of enzyme activity on day 8 which was correlated with the onset of proliferation of presumptive osteoblasts and vascular endothelial cells. The peak of ornithine decarboxylase activity on day 3 appears to be a demineralized bone matrix-specific event. Induction of ornithine decarboxylase activity represents one of the early responses to implanted bone matrix.
AB - Subcutaneous transplantation of coarse powders of demineralized rat diaphyseal bone matrix into allogeneic recipients results in new bone formation. The changes in ornithine decarboxylase activity during such bone matrix-induced sequential differentiation of cartilage, bone and bone marrow were investigated. There was a peak in ornithine decarboxylase activity on day 3 corresponding to the appearance of fibroblasts in close contiguity to the bone matrix. This was followed by another peak of enzyme activity on day 8 which was correlated with the onset of proliferation of presumptive osteoblasts and vascular endothelial cells. The peak of ornithine decarboxylase activity on day 3 appears to be a demineralized bone matrix-specific event. Induction of ornithine decarboxylase activity represents one of the early responses to implanted bone matrix.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018147505&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(78)91636-4
DO - 10.1016/0006-291X(78)91636-4
M3 - Article
C2 - 350225
AN - SCOPUS:0018147505
VL - 81
SP - 106
EP - 113
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -