Changes in myofibrillar content and Mg-ATPase activity in ventricular tissues from patients with heart failure caused by coronary artery disease, cardiomyopathy, or mitral valve insufficiency

E. D. Pagani, A. A. Alousi, A. M. Grant, T. M. Older, S. W. Dziuban, P. D. Allen

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Force development and shortening by cardiac muscle occur as a result of the interaction between actin and myosin within the myofibrillar lattice. This interaction is dependent upon intracellular ionized calcium and is controlled by the troponin-tropomyosin regulatory proteins situated along the actin filament. In this study, we compared the myofibrillar content and myofibrillar Mg-ATPase activity of normal human ventricular muscle with that of ventricular muscle from patients in end-stage failure caused by coronary artery disease or cardiomyopathy and ventricular muscle from patients with heart failure due to mitral valve insufficiency. The results show that the amount of myofibrillar protein (mg/g wet wt ventricle) in hearts in end-stage failure (coronary artery disease and cardiomyopathy) is significantly lower compared with normal hearts and hearts in failure due to mitral valve insufficiency. However, the Mg-ATPase activity of myofibrils from hearts in both end-stage failure and failure due to mitral valve insufficiency is significantly lower compared with myofibrils from normal hearts. The data suggest that the reduction in the amount of myofibrillar protein in ventricular tissue is a pivotal event that may be responsible for the progression of heart disease to the point of end-stage failure.

Original languageEnglish (US)
Pages (from-to)380-385
Number of pages6
JournalCirculation Research
Volume63
Issue number2
StatePublished - 1988
Externally publishedYes

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Mitral Valve Insufficiency
Cardiomyopathies
Adenosine Triphosphatases
Coronary Artery Disease
Heart Failure
Myofibrils
Muscles
Tropomyosin
Proteins
Troponin
Myosins
Actin Cytoskeleton
Human Activities
Heart Ventricles
Actins
Heart Diseases
Myocardium
Calcium

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Changes in myofibrillar content and Mg-ATPase activity in ventricular tissues from patients with heart failure caused by coronary artery disease, cardiomyopathy, or mitral valve insufficiency. / Pagani, E. D.; Alousi, A. A.; Grant, A. M.; Older, T. M.; Dziuban, S. W.; Allen, P. D.

In: Circulation Research, Vol. 63, No. 2, 1988, p. 380-385.

Research output: Contribution to journalArticle

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AU - Older, T. M.

AU - Dziuban, S. W.

AU - Allen, P. D.

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