Changes in kinetic characteristics of sheep liver microsomes following induction and dietary stress

Dennis W Wilson, Larry G. Hansen

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The effects of dietary stress and polychlorinated biphenyls (PCB) on the kinetic characteristics of ovine liver microsomal oxidases were studied. Curvilinear Lineweaver-Burke kinetic plots were obtained for the O-deethylation of p-nitrophenetole. Increasing linearity of the plots resulted from microsomal induction due to both dietary stress and PCB exposure. This suggests two enzyme systems with different magnitudes of induction catalyzing the same reaction.

Original languageEnglish (US)
Pages (from-to)114-119
Number of pages6
JournalToxicology and Applied Pharmacology
Volume31
Issue number1
DOIs
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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