The effects of dietary stress and polychlorinated biphenyls (PCB) on the kinetic characteristics of ovine liver microsomal oxidases were studied. Curvilinear Lineweaver-Burke kinetic plots were obtained for the O-deethylation of p-nitrophenetole. Increasing linearity of the plots resulted from microsomal induction due to both dietary stress and PCB exposure. This suggests two enzyme systems with different magnitudes of induction catalyzing the same reaction.
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