Changes in hepatic superoxide dismutase activity in alcoholic monkeys

Carl L Keen, T. Tamura, B. Lonnerdal, L. S. Hurley, C. H. Halsted

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The hepatic concentrations of copper, zinc and manganese, the activity of the mitochondrial enzyme manganese-superoxide dismutase (MnSOD), and the activity of the cytosolic enzyme copper-zinc SOD (CuZnSOD) were measured in control and ethanol-fed monkeys. In the ethanol-fed group, liver Zn levels were decreased while the Mn concentration was increased. The activity of MnSOD was higher in the ethanol-fed group while the activity of CuZnSOD tended to be lower. The finding of increased activity of MnSOD is consistent with the finding of enlarged mitochondria and increased liver Mn in the ethanol-fed group. Increased MnSOD may reflect substrate induction, since superoxide anions are generated by ethanol metabolism. On the other hand, insufficient CuZnSOD activity may contribute to increased ethanol-induced lipid peroxidation with resultant mitochondrial damage. Thus, the chronic consumption of ethanol results in altered levels of trace minerals and SOD activities in the liver which in turn may contribute to hepatic injury.

Original languageEnglish (US)
Pages (from-to)929-932
Number of pages4
JournalAmerican Journal of Clinical Nutrition
Volume41
Issue number5
StatePublished - 1985

Fingerprint

alcohol abuse
Superoxide Dismutase
Haplorhini
monkeys
superoxide dismutase
Ethanol
ethanol
manganese
liver
Liver
Zinc
Copper
copper
zinc
Liver Mitochondrion
Trace Elements
Enzymes
Manganese
Superoxides
superoxide anion

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Keen, C. L., Tamura, T., Lonnerdal, B., Hurley, L. S., & Halsted, C. H. (1985). Changes in hepatic superoxide dismutase activity in alcoholic monkeys. American Journal of Clinical Nutrition, 41(5), 929-932.

Changes in hepatic superoxide dismutase activity in alcoholic monkeys. / Keen, Carl L; Tamura, T.; Lonnerdal, B.; Hurley, L. S.; Halsted, C. H.

In: American Journal of Clinical Nutrition, Vol. 41, No. 5, 1985, p. 929-932.

Research output: Contribution to journalArticle

Keen, CL, Tamura, T, Lonnerdal, B, Hurley, LS & Halsted, CH 1985, 'Changes in hepatic superoxide dismutase activity in alcoholic monkeys', American Journal of Clinical Nutrition, vol. 41, no. 5, pp. 929-932.
Keen CL, Tamura T, Lonnerdal B, Hurley LS, Halsted CH. Changes in hepatic superoxide dismutase activity in alcoholic monkeys. American Journal of Clinical Nutrition. 1985;41(5):929-932.
Keen, Carl L ; Tamura, T. ; Lonnerdal, B. ; Hurley, L. S. ; Halsted, C. H. / Changes in hepatic superoxide dismutase activity in alcoholic monkeys. In: American Journal of Clinical Nutrition. 1985 ; Vol. 41, No. 5. pp. 929-932.
@article{9579ee67658d479996a86b901b158c59,
title = "Changes in hepatic superoxide dismutase activity in alcoholic monkeys",
abstract = "The hepatic concentrations of copper, zinc and manganese, the activity of the mitochondrial enzyme manganese-superoxide dismutase (MnSOD), and the activity of the cytosolic enzyme copper-zinc SOD (CuZnSOD) were measured in control and ethanol-fed monkeys. In the ethanol-fed group, liver Zn levels were decreased while the Mn concentration was increased. The activity of MnSOD was higher in the ethanol-fed group while the activity of CuZnSOD tended to be lower. The finding of increased activity of MnSOD is consistent with the finding of enlarged mitochondria and increased liver Mn in the ethanol-fed group. Increased MnSOD may reflect substrate induction, since superoxide anions are generated by ethanol metabolism. On the other hand, insufficient CuZnSOD activity may contribute to increased ethanol-induced lipid peroxidation with resultant mitochondrial damage. Thus, the chronic consumption of ethanol results in altered levels of trace minerals and SOD activities in the liver which in turn may contribute to hepatic injury.",
author = "Keen, {Carl L} and T. Tamura and B. Lonnerdal and Hurley, {L. S.} and Halsted, {C. H.}",
year = "1985",
language = "English (US)",
volume = "41",
pages = "929--932",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "5",

}

TY - JOUR

T1 - Changes in hepatic superoxide dismutase activity in alcoholic monkeys

AU - Keen, Carl L

AU - Tamura, T.

AU - Lonnerdal, B.

AU - Hurley, L. S.

AU - Halsted, C. H.

PY - 1985

Y1 - 1985

N2 - The hepatic concentrations of copper, zinc and manganese, the activity of the mitochondrial enzyme manganese-superoxide dismutase (MnSOD), and the activity of the cytosolic enzyme copper-zinc SOD (CuZnSOD) were measured in control and ethanol-fed monkeys. In the ethanol-fed group, liver Zn levels were decreased while the Mn concentration was increased. The activity of MnSOD was higher in the ethanol-fed group while the activity of CuZnSOD tended to be lower. The finding of increased activity of MnSOD is consistent with the finding of enlarged mitochondria and increased liver Mn in the ethanol-fed group. Increased MnSOD may reflect substrate induction, since superoxide anions are generated by ethanol metabolism. On the other hand, insufficient CuZnSOD activity may contribute to increased ethanol-induced lipid peroxidation with resultant mitochondrial damage. Thus, the chronic consumption of ethanol results in altered levels of trace minerals and SOD activities in the liver which in turn may contribute to hepatic injury.

AB - The hepatic concentrations of copper, zinc and manganese, the activity of the mitochondrial enzyme manganese-superoxide dismutase (MnSOD), and the activity of the cytosolic enzyme copper-zinc SOD (CuZnSOD) were measured in control and ethanol-fed monkeys. In the ethanol-fed group, liver Zn levels were decreased while the Mn concentration was increased. The activity of MnSOD was higher in the ethanol-fed group while the activity of CuZnSOD tended to be lower. The finding of increased activity of MnSOD is consistent with the finding of enlarged mitochondria and increased liver Mn in the ethanol-fed group. Increased MnSOD may reflect substrate induction, since superoxide anions are generated by ethanol metabolism. On the other hand, insufficient CuZnSOD activity may contribute to increased ethanol-induced lipid peroxidation with resultant mitochondrial damage. Thus, the chronic consumption of ethanol results in altered levels of trace minerals and SOD activities in the liver which in turn may contribute to hepatic injury.

UR - http://www.scopus.com/inward/record.url?scp=0021797391&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021797391&partnerID=8YFLogxK

M3 - Article

C2 - 4039529

AN - SCOPUS:0021797391

VL - 41

SP - 929

EP - 932

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 5

ER -