Changes in cerebrospinal fluid and plasma amino acid concentrations with elevated dietary protein concentration in dogs with portacaval shunts

Monica C. Schaeffer, Quinton Rogers, Philip M.B. Leung, Bruce M. Wolfe, Donald R. Strombeck

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Effects of dietary protein concentration on plasma and cerebrospinal fluid (CSF) amino acids (AA) in dogs with portacaval shunts (PCS) were examined. An 18% protein purified diet (18P) was fed to 4 PCS dogs and 2 controls; at week 10, 2 of the PCS dogs were switched to 36% protein (36P) until week 28. Effects of the diet switch on plasma and CSF AA in 8 normal dogs were determined in another experiment. Neither surgery nor protein level significantly affected average food intake (weeks 10-28). Plasma amino acid patterns typical of PCS animals were observed: phenylalanine and tyrosine increased and branched chain AA decreased with shunting (p<0.05). Plasma phenylalanine increased further with 36P in PCS dogs (p<0.05), but was not affected by dietary protein concentration in controls. With 36P: CSF arginine, serine, histidine, tryptophan, phenylalanine, glutamate and glutamine increased in PCS dogs; but only arginine decreased in CSF of controls (p<0.05). In PCS dogs, significant CSF AA changes with elevated dietary protein were unrelated to plasma AA changes.

Original languageEnglish (US)
Pages (from-to)2215-2223
Number of pages9
JournalLife Sciences
Volume48
Issue number23
DOIs
StatePublished - Jan 1 1991

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Surgical Portacaval Shunt
Cerebrospinal fluid
Dietary Proteins
Cerebrospinal Fluid
Dogs
Plasmas
Amino Acids
Phenylalanine
Nutrition
Arginine
Proteins
Cerebrospinal Fluid Proteins
Branched Chain Amino Acids
Glutamine
Histidine
Diet
Tryptophan
Surgery
Serine
Tyrosine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Changes in cerebrospinal fluid and plasma amino acid concentrations with elevated dietary protein concentration in dogs with portacaval shunts. / Schaeffer, Monica C.; Rogers, Quinton; Leung, Philip M.B.; Wolfe, Bruce M.; Strombeck, Donald R.

In: Life Sciences, Vol. 48, No. 23, 01.01.1991, p. 2215-2223.

Research output: Contribution to journalArticle

Schaeffer, Monica C. ; Rogers, Quinton ; Leung, Philip M.B. ; Wolfe, Bruce M. ; Strombeck, Donald R. / Changes in cerebrospinal fluid and plasma amino acid concentrations with elevated dietary protein concentration in dogs with portacaval shunts. In: Life Sciences. 1991 ; Vol. 48, No. 23. pp. 2215-2223.
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