Changes in carotid artery sonogram in premature adrenarche

Revi P. Mathew, Marta Hernanz-Schulman, Wenli Wang, Benjamin Saville, Andrew Bremer

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: Premature adrenarche (PA), the appearance of pubic hair before the age of 8 years in girls and before 9 years in boys, may predict future morbidity, such as metabolic syndrome (MS). Objective: The purpose of this study is to assess carotid artery ultrasound changes in children with PA. Design/methods: PA children were matched with a group of prepubertal controls without PA. Subjects and controls underwent clinical and biochemical evaluation and sonograms of the carotid arteries. Results: Twelve children with PA and their matched controls were studied. Carotid artery ultrasonography showed elevation of the inner and outer diameter of the left carotid, and the cross-sectional area of the lumen and outer wall, and the outer diameter of the right carotid artery in PA. However, none of the above results maintained statistical signifi cance when a Hochberg correction was applied. Conclusions: Carotid artery diameter and cross-sectional area may be useful non-invasive markers of vascular pathology and MS in premature pubarche.

Original languageEnglish (US)
Pages (from-to)139-145
Number of pages7
JournalJournal of Pediatric Endocrinology and Metabolism
Volume25
Issue number1-2
DOIs
StatePublished - Feb 2012
Externally publishedYes

Keywords

  • Dehydroepiandrosterone sulfate
  • Hirsutism
  • Hyperandrogenism
  • Insulin resistance
  • Metabolic syndrome

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

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    Mathew, R. P., Hernanz-Schulman, M., Wang, W., Saville, B., & Bremer, A. (2012). Changes in carotid artery sonogram in premature adrenarche. Journal of Pediatric Endocrinology and Metabolism, 25(1-2), 139-145. https://doi.org/10.1515/JPEM.2011.411