Abstract
Purpose: We described changes in tumor volume on serial biopsies during an extended period in men on active surveillance. Materials and Methods: The study cohort included men diagnosed with prostate cancer between 1998 and 2010 enrolled in active surveillance with 6 or more months of followup. Change in volume over time was assessed as change in percent cores positive, percent cancer in 1 biopsy core and the doubling of total cancer volume (mm). Logistic regression was used to determine the association between grade and volume progression. Results: A total of 399 men met the study inclusion criteria. Mean patient age was 61.8 years old and 313 (78%) had low risk disease. Overall 231 (58%) men had stable disease on repeat biopsies. There were 39 (10%) men with a volume increase, defined by an increase to more than 33% cores involved or an increase in maximum single core positive to more than 50%, and there were 44 (11%) with an increase in volume and grade. Approximately 10% of men experienced a decrease in cancer volume. On multivariate analysis there was a significant association between grade and volume progression on any biopsy (OR 3.07), and a doubling of tumor length (mm) at 5 years (OR 6.30). Conclusions: Prostate cancer volume increases and decreases at a similar rate of 10% per biopsy. An increase in tumor volume is associated with an increase in cancer grade on early repeat biopsies. However, there is a large degree of variation in cancer volume over time.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1825-1829 |
| Number of pages | 5 |
| Journal | Journal of Urology |
| Volume | 186 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 2011 |
| Externally published | Yes |
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Keywords
- biopsy
- prostate
- prostatic neoplasms
- watchful waiting
ASJC Scopus subject areas
- Urology
Cite this
Changes in cancer volume in serial biopsies of men on active surveillance for early stage prostate cancer. / Porten, Sima P.; Whitson, Jared M; Cowan, Janet E.; Perez, Nannette; Shinohara, Katsuto; Carroll, Peter R.
In: Journal of Urology, Vol. 186, No. 5, 11.2011, p. 1825-1829.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Changes in cancer volume in serial biopsies of men on active surveillance for early stage prostate cancer
AU - Porten, Sima P.
AU - Whitson, Jared M
AU - Cowan, Janet E.
AU - Perez, Nannette
AU - Shinohara, Katsuto
AU - Carroll, Peter R.
PY - 2011/11
Y1 - 2011/11
N2 - Purpose: We described changes in tumor volume on serial biopsies during an extended period in men on active surveillance. Materials and Methods: The study cohort included men diagnosed with prostate cancer between 1998 and 2010 enrolled in active surveillance with 6 or more months of followup. Change in volume over time was assessed as change in percent cores positive, percent cancer in 1 biopsy core and the doubling of total cancer volume (mm). Logistic regression was used to determine the association between grade and volume progression. Results: A total of 399 men met the study inclusion criteria. Mean patient age was 61.8 years old and 313 (78%) had low risk disease. Overall 231 (58%) men had stable disease on repeat biopsies. There were 39 (10%) men with a volume increase, defined by an increase to more than 33% cores involved or an increase in maximum single core positive to more than 50%, and there were 44 (11%) with an increase in volume and grade. Approximately 10% of men experienced a decrease in cancer volume. On multivariate analysis there was a significant association between grade and volume progression on any biopsy (OR 3.07), and a doubling of tumor length (mm) at 5 years (OR 6.30). Conclusions: Prostate cancer volume increases and decreases at a similar rate of 10% per biopsy. An increase in tumor volume is associated with an increase in cancer grade on early repeat biopsies. However, there is a large degree of variation in cancer volume over time.
AB - Purpose: We described changes in tumor volume on serial biopsies during an extended period in men on active surveillance. Materials and Methods: The study cohort included men diagnosed with prostate cancer between 1998 and 2010 enrolled in active surveillance with 6 or more months of followup. Change in volume over time was assessed as change in percent cores positive, percent cancer in 1 biopsy core and the doubling of total cancer volume (mm). Logistic regression was used to determine the association between grade and volume progression. Results: A total of 399 men met the study inclusion criteria. Mean patient age was 61.8 years old and 313 (78%) had low risk disease. Overall 231 (58%) men had stable disease on repeat biopsies. There were 39 (10%) men with a volume increase, defined by an increase to more than 33% cores involved or an increase in maximum single core positive to more than 50%, and there were 44 (11%) with an increase in volume and grade. Approximately 10% of men experienced a decrease in cancer volume. On multivariate analysis there was a significant association between grade and volume progression on any biopsy (OR 3.07), and a doubling of tumor length (mm) at 5 years (OR 6.30). Conclusions: Prostate cancer volume increases and decreases at a similar rate of 10% per biopsy. An increase in tumor volume is associated with an increase in cancer grade on early repeat biopsies. However, there is a large degree of variation in cancer volume over time.
KW - biopsy
KW - prostate
KW - prostatic neoplasms
KW - watchful waiting
UR - http://www.scopus.com/inward/record.url?scp=80053956124&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053956124&partnerID=8YFLogxK
U2 - 10.1016/j.juro.2011.06.055
DO - 10.1016/j.juro.2011.06.055
M3 - Article
C2 - 21944082
AN - SCOPUS:80053956124
VL - 186
SP - 1825
EP - 1829
JO - Journal of Urology
JF - Journal of Urology
SN - 0022-5347
IS - 5
ER -