Changes in cancer volume in serial biopsies of men on active surveillance for early stage prostate cancer

Sima P. Porten, Jared M Whitson, Janet E. Cowan, Nannette Perez, Katsuto Shinohara, Peter R. Carroll

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Purpose: We described changes in tumor volume on serial biopsies during an extended period in men on active surveillance. Materials and Methods: The study cohort included men diagnosed with prostate cancer between 1998 and 2010 enrolled in active surveillance with 6 or more months of followup. Change in volume over time was assessed as change in percent cores positive, percent cancer in 1 biopsy core and the doubling of total cancer volume (mm). Logistic regression was used to determine the association between grade and volume progression. Results: A total of 399 men met the study inclusion criteria. Mean patient age was 61.8 years old and 313 (78%) had low risk disease. Overall 231 (58%) men had stable disease on repeat biopsies. There were 39 (10%) men with a volume increase, defined by an increase to more than 33% cores involved or an increase in maximum single core positive to more than 50%, and there were 44 (11%) with an increase in volume and grade. Approximately 10% of men experienced a decrease in cancer volume. On multivariate analysis there was a significant association between grade and volume progression on any biopsy (OR 3.07), and a doubling of tumor length (mm) at 5 years (OR 6.30). Conclusions: Prostate cancer volume increases and decreases at a similar rate of 10% per biopsy. An increase in tumor volume is associated with an increase in cancer grade on early repeat biopsies. However, there is a large degree of variation in cancer volume over time.

Original languageEnglish (US)
Pages (from-to)1825-1829
Number of pages5
JournalJournal of Urology
Volume186
Issue number5
DOIs
StatePublished - Nov 2011
Externally publishedYes

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Prostatic Neoplasms
Biopsy
Neoplasms
Tumor Burden
Cohort Studies
Multivariate Analysis
Logistic Models

Keywords

  • biopsy
  • prostate
  • prostatic neoplasms
  • watchful waiting

ASJC Scopus subject areas

  • Urology

Cite this

Porten, S. P., Whitson, J. M., Cowan, J. E., Perez, N., Shinohara, K., & Carroll, P. R. (2011). Changes in cancer volume in serial biopsies of men on active surveillance for early stage prostate cancer. Journal of Urology, 186(5), 1825-1829. https://doi.org/10.1016/j.juro.2011.06.055

Changes in cancer volume in serial biopsies of men on active surveillance for early stage prostate cancer. / Porten, Sima P.; Whitson, Jared M; Cowan, Janet E.; Perez, Nannette; Shinohara, Katsuto; Carroll, Peter R.

In: Journal of Urology, Vol. 186, No. 5, 11.2011, p. 1825-1829.

Research output: Contribution to journalArticle

Porten, SP, Whitson, JM, Cowan, JE, Perez, N, Shinohara, K & Carroll, PR 2011, 'Changes in cancer volume in serial biopsies of men on active surveillance for early stage prostate cancer', Journal of Urology, vol. 186, no. 5, pp. 1825-1829. https://doi.org/10.1016/j.juro.2011.06.055
Porten, Sima P. ; Whitson, Jared M ; Cowan, Janet E. ; Perez, Nannette ; Shinohara, Katsuto ; Carroll, Peter R. / Changes in cancer volume in serial biopsies of men on active surveillance for early stage prostate cancer. In: Journal of Urology. 2011 ; Vol. 186, No. 5. pp. 1825-1829.
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