Changes in blood pressure following escalating doses of phenylpropanolamine and a suggested protocol for monitoring

Gilad Segev, Joellen L Westropp, Chen Kulik, Eran Lavy

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

This prospective, cross-over, blinded study evaluated the effect of various doses of phenylpropanolamine (PPA) on blood pressure in dogs. Dogs were randomized to receive a placebo or 1 of 3 dosages of immediate release PPA, ql2h for 7 days [1 mg/kg body weight (BW), 2 mg/kg BW, or 4 mg/kg BW] in a cross-over design. Blood pressure was recorded every 2 h, for 12 h, on days 1 and 7. There were significant increases in systolic, diastolic, and mean blood pressure following administration of PPA at 2 mg/kg BW and 4 mg/kg BW. A significant decrease in heart rate was also noted at all PPA dosages, but not in the placebo. Administration of PPA was associated with a dose response increase in blood pressure. Dosages of up to 2 mg/kg BW should be considered safe in healthy dogs.

Original languageEnglish (US)
Pages (from-to)39-43
Number of pages5
JournalCanadian Veterinary Journal
Volume56
Issue number1
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • veterinary(all)

Fingerprint Dive into the research topics of 'Changes in blood pressure following escalating doses of phenylpropanolamine and a suggested protocol for monitoring'. Together they form a unique fingerprint.

  • Cite this