Changes in alcohol use associated with changes in HIV disease severity over time

A national longitudinal study in the Veterans Aging Cohort

Emily C. Williams, Kathleen A. McGinnis, Jennifer F. Bobb, Anna D. Rubinsky, Gwen T. Lapham, Melissa Skanderson, Sheryl L Catz, Kara M. Bensley, Julie E. Richards, Kendall J. Bryant, E. Jennifer Edelman, Derek D. Satre, Brandon D.L. Marshall, Kevin L. Kraemer, John R. Blosnich, Stephen Crystal, Adam J. Gordon, David A. Fiellin, Amy C. Justice, Katharine A. Bradley

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Among groups of persons living with HIV (PLWH), high-risk drinking trajectories are associated with HIV severity. Whether changes in individuals’ alcohol use are associated with changes in HIV severity over the same period is unknown. Methods: Veterans Aging Cohort Study (VACS) data from VA's EHR (2/1/2008-9/30/2016) identified AUDIT-C screens for all PLWH. Pairs of AUDIT-C screens within 9–15 months were included if CD4 and/or viral load (VL) was measured within 9 months after baseline and follow-up AUDIT-Cs. Linear regression assessed change in HIV severity (CD4 and logVL) associated with AUDIT-C change adjusted for confounders. Mean changes in HIV severity were estimated for each AUDIT-C change value. For all measures of change, positive values indicate improvements (lower drinking and improved HIV severity). Results: Among PLWH, 21,999 and 22,143 were eligible for CD4 and VL analyses, respectively. Most had non- or low-level drinking and stable consumption over time (mean AUDIT-C change =.08, SD = 1.91). HIV severity improved over time [mean CD4 change = 20.5 (SD 180.8); mean logVL change = 0.12 (SD 0.71)]. AUDIT-C changes were associated non-linearly with changes in CD4 (p = 0.03) and logVL (p < 0.001). Improvement in HIV severity was greatest among those with stable AUDIT-C scores over time; those with greater AUDIT-C increases fared worse than those with smaller increases in or stable AUDIT-Cs. Conclusions: Improvement in HIV severity was greatest among PLWH with relatively stable drinking, most of whom initially did not drink or drank at low levels. Those with large changes (especially increases) in drinking appear at greatest risk for poor HIV control.

Original languageEnglish (US)
Pages (from-to)21-29
Number of pages9
JournalDrug and Alcohol Dependence
Volume189
DOIs
StatePublished - Aug 1 2018

Fingerprint

Veterans
Longitudinal Studies
Aging of materials
Alcohols
HIV
Linear regression
Trajectories
Drinking
Viral Load
M 92
Linear Models
Cohort Studies

Keywords

  • Alcohol use
  • Alcohol use disorders
  • CD4
  • HIV
  • Veterans
  • Viral load

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

Changes in alcohol use associated with changes in HIV disease severity over time : A national longitudinal study in the Veterans Aging Cohort. / Williams, Emily C.; McGinnis, Kathleen A.; Bobb, Jennifer F.; Rubinsky, Anna D.; Lapham, Gwen T.; Skanderson, Melissa; Catz, Sheryl L; Bensley, Kara M.; Richards, Julie E.; Bryant, Kendall J.; Edelman, E. Jennifer; Satre, Derek D.; Marshall, Brandon D.L.; Kraemer, Kevin L.; Blosnich, John R.; Crystal, Stephen; Gordon, Adam J.; Fiellin, David A.; Justice, Amy C.; Bradley, Katharine A.

In: Drug and Alcohol Dependence, Vol. 189, 01.08.2018, p. 21-29.

Research output: Contribution to journalArticle

Williams, EC, McGinnis, KA, Bobb, JF, Rubinsky, AD, Lapham, GT, Skanderson, M, Catz, SL, Bensley, KM, Richards, JE, Bryant, KJ, Edelman, EJ, Satre, DD, Marshall, BDL, Kraemer, KL, Blosnich, JR, Crystal, S, Gordon, AJ, Fiellin, DA, Justice, AC & Bradley, KA 2018, 'Changes in alcohol use associated with changes in HIV disease severity over time: A national longitudinal study in the Veterans Aging Cohort', Drug and Alcohol Dependence, vol. 189, pp. 21-29. https://doi.org/10.1016/j.drugalcdep.2018.04.022
Williams, Emily C. ; McGinnis, Kathleen A. ; Bobb, Jennifer F. ; Rubinsky, Anna D. ; Lapham, Gwen T. ; Skanderson, Melissa ; Catz, Sheryl L ; Bensley, Kara M. ; Richards, Julie E. ; Bryant, Kendall J. ; Edelman, E. Jennifer ; Satre, Derek D. ; Marshall, Brandon D.L. ; Kraemer, Kevin L. ; Blosnich, John R. ; Crystal, Stephen ; Gordon, Adam J. ; Fiellin, David A. ; Justice, Amy C. ; Bradley, Katharine A. / Changes in alcohol use associated with changes in HIV disease severity over time : A national longitudinal study in the Veterans Aging Cohort. In: Drug and Alcohol Dependence. 2018 ; Vol. 189. pp. 21-29.
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abstract = "Background: Among groups of persons living with HIV (PLWH), high-risk drinking trajectories are associated with HIV severity. Whether changes in individuals’ alcohol use are associated with changes in HIV severity over the same period is unknown. Methods: Veterans Aging Cohort Study (VACS) data from VA's EHR (2/1/2008-9/30/2016) identified AUDIT-C screens for all PLWH. Pairs of AUDIT-C screens within 9–15 months were included if CD4 and/or viral load (VL) was measured within 9 months after baseline and follow-up AUDIT-Cs. Linear regression assessed change in HIV severity (CD4 and logVL) associated with AUDIT-C change adjusted for confounders. Mean changes in HIV severity were estimated for each AUDIT-C change value. For all measures of change, positive values indicate improvements (lower drinking and improved HIV severity). Results: Among PLWH, 21,999 and 22,143 were eligible for CD4 and VL analyses, respectively. Most had non- or low-level drinking and stable consumption over time (mean AUDIT-C change =.08, SD = 1.91). HIV severity improved over time [mean CD4 change = 20.5 (SD 180.8); mean logVL change = 0.12 (SD 0.71)]. AUDIT-C changes were associated non-linearly with changes in CD4 (p = 0.03) and logVL (p < 0.001). Improvement in HIV severity was greatest among those with stable AUDIT-C scores over time; those with greater AUDIT-C increases fared worse than those with smaller increases in or stable AUDIT-Cs. Conclusions: Improvement in HIV severity was greatest among PLWH with relatively stable drinking, most of whom initially did not drink or drank at low levels. Those with large changes (especially increases) in drinking appear at greatest risk for poor HIV control.",
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T1 - Changes in alcohol use associated with changes in HIV disease severity over time

T2 - A national longitudinal study in the Veterans Aging Cohort

AU - Williams, Emily C.

AU - McGinnis, Kathleen A.

AU - Bobb, Jennifer F.

AU - Rubinsky, Anna D.

AU - Lapham, Gwen T.

AU - Skanderson, Melissa

AU - Catz, Sheryl L

AU - Bensley, Kara M.

AU - Richards, Julie E.

AU - Bryant, Kendall J.

AU - Edelman, E. Jennifer

AU - Satre, Derek D.

AU - Marshall, Brandon D.L.

AU - Kraemer, Kevin L.

AU - Blosnich, John R.

AU - Crystal, Stephen

AU - Gordon, Adam J.

AU - Fiellin, David A.

AU - Justice, Amy C.

AU - Bradley, Katharine A.

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N2 - Background: Among groups of persons living with HIV (PLWH), high-risk drinking trajectories are associated with HIV severity. Whether changes in individuals’ alcohol use are associated with changes in HIV severity over the same period is unknown. Methods: Veterans Aging Cohort Study (VACS) data from VA's EHR (2/1/2008-9/30/2016) identified AUDIT-C screens for all PLWH. Pairs of AUDIT-C screens within 9–15 months were included if CD4 and/or viral load (VL) was measured within 9 months after baseline and follow-up AUDIT-Cs. Linear regression assessed change in HIV severity (CD4 and logVL) associated with AUDIT-C change adjusted for confounders. Mean changes in HIV severity were estimated for each AUDIT-C change value. For all measures of change, positive values indicate improvements (lower drinking and improved HIV severity). Results: Among PLWH, 21,999 and 22,143 were eligible for CD4 and VL analyses, respectively. Most had non- or low-level drinking and stable consumption over time (mean AUDIT-C change =.08, SD = 1.91). HIV severity improved over time [mean CD4 change = 20.5 (SD 180.8); mean logVL change = 0.12 (SD 0.71)]. AUDIT-C changes were associated non-linearly with changes in CD4 (p = 0.03) and logVL (p < 0.001). Improvement in HIV severity was greatest among those with stable AUDIT-C scores over time; those with greater AUDIT-C increases fared worse than those with smaller increases in or stable AUDIT-Cs. Conclusions: Improvement in HIV severity was greatest among PLWH with relatively stable drinking, most of whom initially did not drink or drank at low levels. Those with large changes (especially increases) in drinking appear at greatest risk for poor HIV control.

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KW - Alcohol use disorders

KW - CD4

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KW - Veterans

KW - Viral load

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