Change in serum measurements of cartilage oligomeric matrix protein and association with the development and worsening of radiographic hip osteoarthritis

R. K. Chaganti, A. Kelman, L. Lui, Wei Yao, M. K. Javaid, D. Bauer, M. Nevitt, Nancy E Lane, the Study of Osteoporotic Fractures Research Group (SOF) for the Study of Osteoporotic Fractures Research Group (SOF)

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Objective: To determine the association between changes in serum levels of cartilage oligomeric matrix protein (COMP) and serum N-telopeptide crosslinks (NTX) over a 6-year interval with the development and progression of radiographically apparent hip osteoarthritis (RHOA) in a community sample of elderly women over 8.3 years of follow-up. Methods: Pelvic radiographs were obtained a mean of 8.3 years apart in Caucasian women ≥65 years of age enrolled in the Study of Osteoporotic Fractures. From a cohort of 5928 subjects, we randomly sampled study subjects (∼170 per group) to perform two nested case-control studies, one of RHOA incidence and the other of RHOA progression. Baseline and year 6 serum COMP and serum NTX levels were measured by enzyme linked immunosorbent assay in duplicate and percentage change in serum levels was calculated. Odds ratios (ORs) and 95% confidence intervals (CIs) for 1 standard deviation (SD) change in the serum COMP and NTX level differences were calculated using logistic regression analysis and used to predict the development or progression of RHOA, adjusting for potential covariates. Results: The percentage change in the level of serum COMP from baseline to year 6 was found to be a risk factor for the development of incident RHOA [adjusted OR of 1.58 per 1 SD increase (95% CI: 1.19-2.09)], and reduction of progression of RHOA [adjusted OR of 0.74 per 1 SD increase (95% CI: 0.58-0.96)]. Quartile analysis of serum COMP changes revealed that the three highest quartiles of change in serum COMP were associated with (1) a five-fold greater risk of developing incident RHOA [adjusted OR = 5.42 (95% CI: 2.80-10.60)], and (2) a 50% decreased risk of developing progression of RHOA [adjusted OR = 0.48 (95% CI: 0.30-0.80)]. No significant association was found between changes in serum NTX levels from baseline to year 6 with either incident RHOA or the progression of existing RHOA. Conclusion: Measurement of serum COMP at two distinct timepoints may be a method of identifying patients at risk for developing incident RHOA and those with baseline RHOA that will not rapidly progress.

Original languageEnglish (US)
Pages (from-to)566-571
Number of pages6
JournalOsteoarthritis and Cartilage
Volume16
Issue number5
DOIs
StatePublished - May 2008

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Cartilage Oligomeric Matrix Protein
Hip Osteoarthritis
Cartilage
Association reactions
Proteins
Serum
Blood Proteins
Odds Ratio
Confidence Intervals
Regression analysis
Logistics
Assays
Enzymes
Osteoporotic Fractures

Keywords

  • Biomarkers
  • Cartilage

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Chaganti, R. K., Kelman, A., Lui, L., Yao, W., Javaid, M. K., Bauer, D., ... for the Study of Osteoporotic Fractures Research Group (SOF), T. S. O. O. F. R. G. SOF. (2008). Change in serum measurements of cartilage oligomeric matrix protein and association with the development and worsening of radiographic hip osteoarthritis. Osteoarthritis and Cartilage, 16(5), 566-571. https://doi.org/10.1016/j.joca.2007.09.008

Change in serum measurements of cartilage oligomeric matrix protein and association with the development and worsening of radiographic hip osteoarthritis. / Chaganti, R. K.; Kelman, A.; Lui, L.; Yao, Wei; Javaid, M. K.; Bauer, D.; Nevitt, M.; Lane, Nancy E; for the Study of Osteoporotic Fractures Research Group (SOF), the Study of Osteoporotic Fractures Research Group (SOF).

In: Osteoarthritis and Cartilage, Vol. 16, No. 5, 05.2008, p. 566-571.

Research output: Contribution to journalArticle

Chaganti, RK, Kelman, A, Lui, L, Yao, W, Javaid, MK, Bauer, D, Nevitt, M, Lane, NE & for the Study of Osteoporotic Fractures Research Group (SOF), TSOOFRGSOF 2008, 'Change in serum measurements of cartilage oligomeric matrix protein and association with the development and worsening of radiographic hip osteoarthritis', Osteoarthritis and Cartilage, vol. 16, no. 5, pp. 566-571. https://doi.org/10.1016/j.joca.2007.09.008
Chaganti, R. K. ; Kelman, A. ; Lui, L. ; Yao, Wei ; Javaid, M. K. ; Bauer, D. ; Nevitt, M. ; Lane, Nancy E ; for the Study of Osteoporotic Fractures Research Group (SOF), the Study of Osteoporotic Fractures Research Group (SOF). / Change in serum measurements of cartilage oligomeric matrix protein and association with the development and worsening of radiographic hip osteoarthritis. In: Osteoarthritis and Cartilage. 2008 ; Vol. 16, No. 5. pp. 566-571.
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abstract = "Objective: To determine the association between changes in serum levels of cartilage oligomeric matrix protein (COMP) and serum N-telopeptide crosslinks (NTX) over a 6-year interval with the development and progression of radiographically apparent hip osteoarthritis (RHOA) in a community sample of elderly women over 8.3 years of follow-up. Methods: Pelvic radiographs were obtained a mean of 8.3 years apart in Caucasian women ≥65 years of age enrolled in the Study of Osteoporotic Fractures. From a cohort of 5928 subjects, we randomly sampled study subjects (∼170 per group) to perform two nested case-control studies, one of RHOA incidence and the other of RHOA progression. Baseline and year 6 serum COMP and serum NTX levels were measured by enzyme linked immunosorbent assay in duplicate and percentage change in serum levels was calculated. Odds ratios (ORs) and 95{\%} confidence intervals (CIs) for 1 standard deviation (SD) change in the serum COMP and NTX level differences were calculated using logistic regression analysis and used to predict the development or progression of RHOA, adjusting for potential covariates. Results: The percentage change in the level of serum COMP from baseline to year 6 was found to be a risk factor for the development of incident RHOA [adjusted OR of 1.58 per 1 SD increase (95{\%} CI: 1.19-2.09)], and reduction of progression of RHOA [adjusted OR of 0.74 per 1 SD increase (95{\%} CI: 0.58-0.96)]. Quartile analysis of serum COMP changes revealed that the three highest quartiles of change in serum COMP were associated with (1) a five-fold greater risk of developing incident RHOA [adjusted OR = 5.42 (95{\%} CI: 2.80-10.60)], and (2) a 50{\%} decreased risk of developing progression of RHOA [adjusted OR = 0.48 (95{\%} CI: 0.30-0.80)]. No significant association was found between changes in serum NTX levels from baseline to year 6 with either incident RHOA or the progression of existing RHOA. Conclusion: Measurement of serum COMP at two distinct timepoints may be a method of identifying patients at risk for developing incident RHOA and those with baseline RHOA that will not rapidly progress.",
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T1 - Change in serum measurements of cartilage oligomeric matrix protein and association with the development and worsening of radiographic hip osteoarthritis

AU - Chaganti, R. K.

AU - Kelman, A.

AU - Lui, L.

AU - Yao, Wei

AU - Javaid, M. K.

AU - Bauer, D.

AU - Nevitt, M.

AU - Lane, Nancy E

AU - for the Study of Osteoporotic Fractures Research Group (SOF), the Study of Osteoporotic Fractures Research Group (SOF)

PY - 2008/5

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N2 - Objective: To determine the association between changes in serum levels of cartilage oligomeric matrix protein (COMP) and serum N-telopeptide crosslinks (NTX) over a 6-year interval with the development and progression of radiographically apparent hip osteoarthritis (RHOA) in a community sample of elderly women over 8.3 years of follow-up. Methods: Pelvic radiographs were obtained a mean of 8.3 years apart in Caucasian women ≥65 years of age enrolled in the Study of Osteoporotic Fractures. From a cohort of 5928 subjects, we randomly sampled study subjects (∼170 per group) to perform two nested case-control studies, one of RHOA incidence and the other of RHOA progression. Baseline and year 6 serum COMP and serum NTX levels were measured by enzyme linked immunosorbent assay in duplicate and percentage change in serum levels was calculated. Odds ratios (ORs) and 95% confidence intervals (CIs) for 1 standard deviation (SD) change in the serum COMP and NTX level differences were calculated using logistic regression analysis and used to predict the development or progression of RHOA, adjusting for potential covariates. Results: The percentage change in the level of serum COMP from baseline to year 6 was found to be a risk factor for the development of incident RHOA [adjusted OR of 1.58 per 1 SD increase (95% CI: 1.19-2.09)], and reduction of progression of RHOA [adjusted OR of 0.74 per 1 SD increase (95% CI: 0.58-0.96)]. Quartile analysis of serum COMP changes revealed that the three highest quartiles of change in serum COMP were associated with (1) a five-fold greater risk of developing incident RHOA [adjusted OR = 5.42 (95% CI: 2.80-10.60)], and (2) a 50% decreased risk of developing progression of RHOA [adjusted OR = 0.48 (95% CI: 0.30-0.80)]. No significant association was found between changes in serum NTX levels from baseline to year 6 with either incident RHOA or the progression of existing RHOA. Conclusion: Measurement of serum COMP at two distinct timepoints may be a method of identifying patients at risk for developing incident RHOA and those with baseline RHOA that will not rapidly progress.

AB - Objective: To determine the association between changes in serum levels of cartilage oligomeric matrix protein (COMP) and serum N-telopeptide crosslinks (NTX) over a 6-year interval with the development and progression of radiographically apparent hip osteoarthritis (RHOA) in a community sample of elderly women over 8.3 years of follow-up. Methods: Pelvic radiographs were obtained a mean of 8.3 years apart in Caucasian women ≥65 years of age enrolled in the Study of Osteoporotic Fractures. From a cohort of 5928 subjects, we randomly sampled study subjects (∼170 per group) to perform two nested case-control studies, one of RHOA incidence and the other of RHOA progression. Baseline and year 6 serum COMP and serum NTX levels were measured by enzyme linked immunosorbent assay in duplicate and percentage change in serum levels was calculated. Odds ratios (ORs) and 95% confidence intervals (CIs) for 1 standard deviation (SD) change in the serum COMP and NTX level differences were calculated using logistic regression analysis and used to predict the development or progression of RHOA, adjusting for potential covariates. Results: The percentage change in the level of serum COMP from baseline to year 6 was found to be a risk factor for the development of incident RHOA [adjusted OR of 1.58 per 1 SD increase (95% CI: 1.19-2.09)], and reduction of progression of RHOA [adjusted OR of 0.74 per 1 SD increase (95% CI: 0.58-0.96)]. Quartile analysis of serum COMP changes revealed that the three highest quartiles of change in serum COMP were associated with (1) a five-fold greater risk of developing incident RHOA [adjusted OR = 5.42 (95% CI: 2.80-10.60)], and (2) a 50% decreased risk of developing progression of RHOA [adjusted OR = 0.48 (95% CI: 0.30-0.80)]. No significant association was found between changes in serum NTX levels from baseline to year 6 with either incident RHOA or the progression of existing RHOA. Conclusion: Measurement of serum COMP at two distinct timepoints may be a method of identifying patients at risk for developing incident RHOA and those with baseline RHOA that will not rapidly progress.

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