Change in serum β-human chorionic gonadotropin after abortion with methotrexate and misoprostol

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

OBJECTIVE: The purpose of this study was to determine the normal β-human chorionic gonadotropin change within 24 hours after a medical abortion. Because a medical abortion creates a 'miscarriage,' these data can represent the serum β-human chorionic gonadotropin changes that would occur with a complete spontaneous abortion. Knowledge of normal β-human chorionic gonadotropin changes after a spontaneous abortion may help to differentiate within a 24-hour period a complete from an incomplete spontaneous abortion or an ectopic pregnancy. STUDY DESIGN: Data from recent trials that used methotrexate and misoprostol for abortion at ≤56 days' gestation were reviewed. Patients from each of four trials were included in this analysis if (1) they received both methotrexate intramuscularly and misoprostol vaginally and (2) they had serum β-human chorionic gonadotropin levels drawn on both the day of misoprostol administration and the next day. RESULTS: The change in serum β-human chorionic gonadotropin was evaluated in 86 patients. Subjects who had a complete abortion after receiving methotrexate and a single dose of misoprostol had a decline in serum β-human chorionic gonadotropin of 66% ± 8%. All other subjects had a decline of 25% ± 19% (p = 0.0001). CONCLUSIONS: An aborting pregnancy, if the abortion has occurred, should have a β-human chorionic gonadotropin decrease of at least 48% within approximately 24 hours. This decline, however, does not guarantee that the abortion is complete. A patient with s serum β-human chorionic gonadotropin level that has not declined by a minimum of approximately 50% over 24 hours is unlikely to have a complete abortion.

Original languageEnglish (US)
Pages (from-to)776-778
Number of pages3
JournalAmerican Journal of Obstetrics and Gynecology
Volume174
Issue number2
DOIs
StatePublished - 1996
Externally publishedYes

Fingerprint

Misoprostol
Chorionic Gonadotropin
Methotrexate
Spontaneous Abortion
Serum
Incomplete Abortion
Pregnancy
Ectopic Pregnancy

Keywords

  • β-human chorionic gonadotropin
  • abortion
  • Methotrexate
  • misoprostol
  • serum

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

@article{74eb0193793d4be59a185c8156cba0e9,
title = "Change in serum β-human chorionic gonadotropin after abortion with methotrexate and misoprostol",
abstract = "OBJECTIVE: The purpose of this study was to determine the normal β-human chorionic gonadotropin change within 24 hours after a medical abortion. Because a medical abortion creates a 'miscarriage,' these data can represent the serum β-human chorionic gonadotropin changes that would occur with a complete spontaneous abortion. Knowledge of normal β-human chorionic gonadotropin changes after a spontaneous abortion may help to differentiate within a 24-hour period a complete from an incomplete spontaneous abortion or an ectopic pregnancy. STUDY DESIGN: Data from recent trials that used methotrexate and misoprostol for abortion at ≤56 days' gestation were reviewed. Patients from each of four trials were included in this analysis if (1) they received both methotrexate intramuscularly and misoprostol vaginally and (2) they had serum β-human chorionic gonadotropin levels drawn on both the day of misoprostol administration and the next day. RESULTS: The change in serum β-human chorionic gonadotropin was evaluated in 86 patients. Subjects who had a complete abortion after receiving methotrexate and a single dose of misoprostol had a decline in serum β-human chorionic gonadotropin of 66{\%} ± 8{\%}. All other subjects had a decline of 25{\%} ± 19{\%} (p = 0.0001). CONCLUSIONS: An aborting pregnancy, if the abortion has occurred, should have a β-human chorionic gonadotropin decrease of at least 48{\%} within approximately 24 hours. This decline, however, does not guarantee that the abortion is complete. A patient with s serum β-human chorionic gonadotropin level that has not declined by a minimum of approximately 50{\%} over 24 hours is unlikely to have a complete abortion.",
keywords = "β-human chorionic gonadotropin, abortion, Methotrexate, misoprostol, serum",
author = "Creinin, {Mitchell D}",
year = "1996",
doi = "10.1016/S0002-9378(96)70463-5",
language = "English (US)",
volume = "174",
pages = "776--778",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Change in serum β-human chorionic gonadotropin after abortion with methotrexate and misoprostol

AU - Creinin, Mitchell D

PY - 1996

Y1 - 1996

N2 - OBJECTIVE: The purpose of this study was to determine the normal β-human chorionic gonadotropin change within 24 hours after a medical abortion. Because a medical abortion creates a 'miscarriage,' these data can represent the serum β-human chorionic gonadotropin changes that would occur with a complete spontaneous abortion. Knowledge of normal β-human chorionic gonadotropin changes after a spontaneous abortion may help to differentiate within a 24-hour period a complete from an incomplete spontaneous abortion or an ectopic pregnancy. STUDY DESIGN: Data from recent trials that used methotrexate and misoprostol for abortion at ≤56 days' gestation were reviewed. Patients from each of four trials were included in this analysis if (1) they received both methotrexate intramuscularly and misoprostol vaginally and (2) they had serum β-human chorionic gonadotropin levels drawn on both the day of misoprostol administration and the next day. RESULTS: The change in serum β-human chorionic gonadotropin was evaluated in 86 patients. Subjects who had a complete abortion after receiving methotrexate and a single dose of misoprostol had a decline in serum β-human chorionic gonadotropin of 66% ± 8%. All other subjects had a decline of 25% ± 19% (p = 0.0001). CONCLUSIONS: An aborting pregnancy, if the abortion has occurred, should have a β-human chorionic gonadotropin decrease of at least 48% within approximately 24 hours. This decline, however, does not guarantee that the abortion is complete. A patient with s serum β-human chorionic gonadotropin level that has not declined by a minimum of approximately 50% over 24 hours is unlikely to have a complete abortion.

AB - OBJECTIVE: The purpose of this study was to determine the normal β-human chorionic gonadotropin change within 24 hours after a medical abortion. Because a medical abortion creates a 'miscarriage,' these data can represent the serum β-human chorionic gonadotropin changes that would occur with a complete spontaneous abortion. Knowledge of normal β-human chorionic gonadotropin changes after a spontaneous abortion may help to differentiate within a 24-hour period a complete from an incomplete spontaneous abortion or an ectopic pregnancy. STUDY DESIGN: Data from recent trials that used methotrexate and misoprostol for abortion at ≤56 days' gestation were reviewed. Patients from each of four trials were included in this analysis if (1) they received both methotrexate intramuscularly and misoprostol vaginally and (2) they had serum β-human chorionic gonadotropin levels drawn on both the day of misoprostol administration and the next day. RESULTS: The change in serum β-human chorionic gonadotropin was evaluated in 86 patients. Subjects who had a complete abortion after receiving methotrexate and a single dose of misoprostol had a decline in serum β-human chorionic gonadotropin of 66% ± 8%. All other subjects had a decline of 25% ± 19% (p = 0.0001). CONCLUSIONS: An aborting pregnancy, if the abortion has occurred, should have a β-human chorionic gonadotropin decrease of at least 48% within approximately 24 hours. This decline, however, does not guarantee that the abortion is complete. A patient with s serum β-human chorionic gonadotropin level that has not declined by a minimum of approximately 50% over 24 hours is unlikely to have a complete abortion.

KW - β-human chorionic gonadotropin

KW - abortion

KW - Methotrexate

KW - misoprostol

KW - serum

UR - http://www.scopus.com/inward/record.url?scp=0029671446&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029671446&partnerID=8YFLogxK

U2 - 10.1016/S0002-9378(96)70463-5

DO - 10.1016/S0002-9378(96)70463-5

M3 - Article

C2 - 8623820

AN - SCOPUS:0029671446

VL - 174

SP - 776

EP - 778

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 2

ER -