Abstract
Physical activity offers many benefits to breast cancer survivors, yet research on physical activity during the immediate period following a breast cancer diagnosis is limited. In a prospective cohort study of 1,696 women diagnosed with invasive breast cancer in the Kaiser Permanente Northern California Medical Care Program from 2006-2009, we describe change in self-reported physical activity levels from around diagnosis to 6 months post-diagnosis and determine factors associated with change. Participants completed a comprehensive physical activity questionnaire at baseline (2 months post-diagnosis) and at follow-up (8 months post-diagnosis). Predictors of physical activity change were determined by multivariable linear regression. Reductions in all physical activity levels were observed (P < 0.0001); mean (SD) change (h/week) of moderate-vigorous physical activity (MVPA) was -1.28 (4.48) and sedentary behavior was -0.83 (6.95). In fully-adjusted models, overweight and obesity were associated with greater declines in MVPA of -1.58 h/week (SD = 0.92) and -1.29 h/week (SD = 0.93), respectively (P = 0.0079). Receipt of chemotherapy only was also associated with a greater decrease in MVPA (-2.12 h/week; SD = 0.92; P < 0.0001), specifically for recreational activities (-1.62 h/week; SD = 0.64; P = 0.0001). These data suggest challenges in maintaining physical activity levels during active treatment among women with breast cancer. Interventions to encourage physical activity in breast cancer survivors should be pursued.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 679-690 |
| Number of pages | 12 |
| Journal | Breast Cancer Research and Treatment |
| Volume | 131 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 2012 |
| Externally published | Yes |
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Keywords
- Breast cancer
- Cancer survivorship
- Chemotherapy
- Cohort studies
- Exercise
- Physical activity
- Radiation therapy
- Sedentary lifestyle
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Change in physical activity during active treatment in a prospective study of breast cancer survivors. / Kwan, Marilyn L.; Sternfeld, Barbara; Ergas, Isaac Joshua; Timperi, Allegra W.; Roh, Janise M.; Hong, Chi Chen; Quesenberry, Charles P.; Kushi, Lawrence H.
In: Breast Cancer Research and Treatment, Vol. 131, No. 2, 01.2012, p. 679-690.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Change in physical activity during active treatment in a prospective study of breast cancer survivors
AU - Kwan, Marilyn L.
AU - Sternfeld, Barbara
AU - Ergas, Isaac Joshua
AU - Timperi, Allegra W.
AU - Roh, Janise M.
AU - Hong, Chi Chen
AU - Quesenberry, Charles P.
AU - Kushi, Lawrence H.
PY - 2012/1
Y1 - 2012/1
N2 - Physical activity offers many benefits to breast cancer survivors, yet research on physical activity during the immediate period following a breast cancer diagnosis is limited. In a prospective cohort study of 1,696 women diagnosed with invasive breast cancer in the Kaiser Permanente Northern California Medical Care Program from 2006-2009, we describe change in self-reported physical activity levels from around diagnosis to 6 months post-diagnosis and determine factors associated with change. Participants completed a comprehensive physical activity questionnaire at baseline (2 months post-diagnosis) and at follow-up (8 months post-diagnosis). Predictors of physical activity change were determined by multivariable linear regression. Reductions in all physical activity levels were observed (P < 0.0001); mean (SD) change (h/week) of moderate-vigorous physical activity (MVPA) was -1.28 (4.48) and sedentary behavior was -0.83 (6.95). In fully-adjusted models, overweight and obesity were associated with greater declines in MVPA of -1.58 h/week (SD = 0.92) and -1.29 h/week (SD = 0.93), respectively (P = 0.0079). Receipt of chemotherapy only was also associated with a greater decrease in MVPA (-2.12 h/week; SD = 0.92; P < 0.0001), specifically for recreational activities (-1.62 h/week; SD = 0.64; P = 0.0001). These data suggest challenges in maintaining physical activity levels during active treatment among women with breast cancer. Interventions to encourage physical activity in breast cancer survivors should be pursued.
AB - Physical activity offers many benefits to breast cancer survivors, yet research on physical activity during the immediate period following a breast cancer diagnosis is limited. In a prospective cohort study of 1,696 women diagnosed with invasive breast cancer in the Kaiser Permanente Northern California Medical Care Program from 2006-2009, we describe change in self-reported physical activity levels from around diagnosis to 6 months post-diagnosis and determine factors associated with change. Participants completed a comprehensive physical activity questionnaire at baseline (2 months post-diagnosis) and at follow-up (8 months post-diagnosis). Predictors of physical activity change were determined by multivariable linear regression. Reductions in all physical activity levels were observed (P < 0.0001); mean (SD) change (h/week) of moderate-vigorous physical activity (MVPA) was -1.28 (4.48) and sedentary behavior was -0.83 (6.95). In fully-adjusted models, overweight and obesity were associated with greater declines in MVPA of -1.58 h/week (SD = 0.92) and -1.29 h/week (SD = 0.93), respectively (P = 0.0079). Receipt of chemotherapy only was also associated with a greater decrease in MVPA (-2.12 h/week; SD = 0.92; P < 0.0001), specifically for recreational activities (-1.62 h/week; SD = 0.64; P = 0.0001). These data suggest challenges in maintaining physical activity levels during active treatment among women with breast cancer. Interventions to encourage physical activity in breast cancer survivors should be pursued.
KW - Breast cancer
KW - Cancer survivorship
KW - Chemotherapy
KW - Cohort studies
KW - Exercise
KW - Physical activity
KW - Radiation therapy
KW - Sedentary lifestyle
UR - http://www.scopus.com/inward/record.url?scp=84856221758&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856221758&partnerID=8YFLogxK
U2 - 10.1007/s10549-011-1788-4
DO - 10.1007/s10549-011-1788-4
M3 - Article
C2 - 21953007
AN - SCOPUS:84856221758
VL - 131
SP - 679
EP - 690
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 2
ER -