Change in neonatal resuscitation guidelines and trends in incidence of meconium aspiration syndrome in California

Vaneet K. Kalra, Henry C. Lee, Lillian Sie, Anura W. Ratnasiri, Mark A. Underwood, Satyan Lakshminrusimha

Research output: Contribution to journalArticle


Objective: To describe trends in the incidence and severity of meconium aspiration syndrome (MAS) around the release of revised Neonatal Resuscitation Program (NRP) guidelines in 2016. Study design: The California Perinatal Quality Care Collaborative database was queried for years 2013–2017 to describe the incidence and outcomes of infants with MAS. Results were analyzed based on both individual years and pre- vs. post-guideline epochs (2013–15 vs. 2017). Result: Incidence of MAS decreased significantly from 2013–15 to 2017 (1.02 to 0.78/1000 births, p < 0.001). Among infants with MAS, delivery room intubations decreased from 2013–15 to 2017 (44.3 vs. 35.1%; p = 0.005), but similar proportion of infants required invasive respiratory support (80.1 vs. 80.8%), inhaled nitric oxide (28.8 vs. 28.4%) or extracorporeal membrane oxygenation (0.81 vs. 0.35%). Conclusion: While the study design precludes confirmation of implementation of the recent NRP recommendation, there was no increase in the incidence or severity of MAS following its release.

Original languageEnglish (US)
Pages (from-to)46-55
Number of pages10
JournalJournal of Perinatology
Issue number1
StatePublished - Jan 1 2020


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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