Challenges of cholangiocarcinoma detection in patients with primary sclerosing cholangitis

James H. Tabibian, Keith D. Lindor

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Primary sclerosing cholangitis (PSC) is a chronic, cholestatic, idiopathic liver disease characterized by fibroobliterative inflammation of the hepatic bile ducts. In a clinically significant proportion of patients, PSC progresses to cirrhosis, end-stage liver disease, and in some cases, cholangiocarcinoma (CCA). The development of CCA in PSC is unpredictable, its surveillance and diagnosis complex, and its treatment options limited unless detected early. Herein we provide a focused review of the current literature regarding CCA surveillance in patients with PSC and discuss the diagnostic and management challenges that exist. Where evidence is limited, we present our perspective and approach as well as directions for future research.

Original languageEnglish (US)
Pages (from-to)50-55
Number of pages6
JournalJournal of Analytical Oncology
Volume1
Issue number1
DOIs
StatePublished - 2012
Externally publishedYes

Fingerprint

Sclerosing Cholangitis
Cholangiocarcinoma
Common Hepatic Duct
End Stage Liver Disease
Bile Ducts
Liver Diseases
Fibrosis
Inflammation
Therapeutics

Keywords

  • Bile duct diseases
  • Bile duct neoplasms
  • Biological tumor marker
  • Cholangiography
  • Cytological techniques
  • Early detection of cancer
  • Fluorescence in situ hybridization
  • Imaging
  • Magnetic resonance imaging
  • Mass screening
  • Neoplasm
  • Ultrasonography

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Challenges of cholangiocarcinoma detection in patients with primary sclerosing cholangitis. / Tabibian, James H.; Lindor, Keith D.

In: Journal of Analytical Oncology, Vol. 1, No. 1, 2012, p. 50-55.

Research output: Contribution to journalArticle

Tabibian, James H. ; Lindor, Keith D. / Challenges of cholangiocarcinoma detection in patients with primary sclerosing cholangitis. In: Journal of Analytical Oncology. 2012 ; Vol. 1, No. 1. pp. 50-55.
@article{121e3357b14c41f8b957c050d60d49ef,
title = "Challenges of cholangiocarcinoma detection in patients with primary sclerosing cholangitis",
abstract = "Primary sclerosing cholangitis (PSC) is a chronic, cholestatic, idiopathic liver disease characterized by fibroobliterative inflammation of the hepatic bile ducts. In a clinically significant proportion of patients, PSC progresses to cirrhosis, end-stage liver disease, and in some cases, cholangiocarcinoma (CCA). The development of CCA in PSC is unpredictable, its surveillance and diagnosis complex, and its treatment options limited unless detected early. Herein we provide a focused review of the current literature regarding CCA surveillance in patients with PSC and discuss the diagnostic and management challenges that exist. Where evidence is limited, we present our perspective and approach as well as directions for future research.",
keywords = "Bile duct diseases, Bile duct neoplasms, Biological tumor marker, Cholangiography, Cytological techniques, Early detection of cancer, Fluorescence in situ hybridization, Imaging, Magnetic resonance imaging, Mass screening, Neoplasm, Ultrasonography",
author = "Tabibian, {James H.} and Lindor, {Keith D.}",
year = "2012",
doi = "10.6000/1927-7229.2012.01.01.7",
language = "English (US)",
volume = "1",
pages = "50--55",
journal = "Journal of Analytical Oncology",
issn = "1927-7210",
publisher = "Lifescience Global",
number = "1",

}

TY - JOUR

T1 - Challenges of cholangiocarcinoma detection in patients with primary sclerosing cholangitis

AU - Tabibian, James H.

AU - Lindor, Keith D.

PY - 2012

Y1 - 2012

N2 - Primary sclerosing cholangitis (PSC) is a chronic, cholestatic, idiopathic liver disease characterized by fibroobliterative inflammation of the hepatic bile ducts. In a clinically significant proportion of patients, PSC progresses to cirrhosis, end-stage liver disease, and in some cases, cholangiocarcinoma (CCA). The development of CCA in PSC is unpredictable, its surveillance and diagnosis complex, and its treatment options limited unless detected early. Herein we provide a focused review of the current literature regarding CCA surveillance in patients with PSC and discuss the diagnostic and management challenges that exist. Where evidence is limited, we present our perspective and approach as well as directions for future research.

AB - Primary sclerosing cholangitis (PSC) is a chronic, cholestatic, idiopathic liver disease characterized by fibroobliterative inflammation of the hepatic bile ducts. In a clinically significant proportion of patients, PSC progresses to cirrhosis, end-stage liver disease, and in some cases, cholangiocarcinoma (CCA). The development of CCA in PSC is unpredictable, its surveillance and diagnosis complex, and its treatment options limited unless detected early. Herein we provide a focused review of the current literature regarding CCA surveillance in patients with PSC and discuss the diagnostic and management challenges that exist. Where evidence is limited, we present our perspective and approach as well as directions for future research.

KW - Bile duct diseases

KW - Bile duct neoplasms

KW - Biological tumor marker

KW - Cholangiography

KW - Cytological techniques

KW - Early detection of cancer

KW - Fluorescence in situ hybridization

KW - Imaging

KW - Magnetic resonance imaging

KW - Mass screening

KW - Neoplasm

KW - Ultrasonography

UR - http://www.scopus.com/inward/record.url?scp=84887422384&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887422384&partnerID=8YFLogxK

U2 - 10.6000/1927-7229.2012.01.01.7

DO - 10.6000/1927-7229.2012.01.01.7

M3 - Article

VL - 1

SP - 50

EP - 55

JO - Journal of Analytical Oncology

JF - Journal of Analytical Oncology

SN - 1927-7210

IS - 1

ER -