Challenges in defining and identifying patients with non-small cell lung cancer and poor performance status

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Performance status (PS), a subjective measure of the functional status of a patient with cancer and his or her ability to perform normal activities, is influenced both by tumor-related and by comorbidity-related factors. It is a reliable independent prognostic indicator for survival in patients with advanced non-small cell lung cancer. Patients with a poor PS (PS2) constitute up to 30% to 40% of the population of patients with advanced non-small cell lung cancer, yet they are underrepresented in clinical trials. These patients are heterogeneous, which makes it challenging to use their PS scores alone to guide their therapy. A greater understanding of PS scores and the factors that affect them can be gained through PS2-specific clinical trials, which can lead to the development of better PS instruments to aid in making therapeutic decisions.

Original languageEnglish (US)
Pages (from-to)3-7
Number of pages5
JournalSeminars in Oncology
Issue numberSUPPL. 11
StatePublished - Dec 2004
Externally publishedYes


ASJC Scopus subject areas

  • Oncology

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