CGRP antagonists and capsaicin on celiac ganglia partly prevent postoperative gastric ileus

Victor Plourde, Helen C. Wong, John H. Walsh, Helen E Raybould, Yvette Taché

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

The role of capsaicin-sensitive pathways and CGRP in postoperative gastric ileus was investigated. Abdominal surgery was performed under enflurane anesthesia, and 5 min later, the 20-min rate of gastric emptying was measured by the phenol red method in conscious rats. Surgery inhibited gastric emptying by 76-83% compared with rats receiving anesthesia alone. Capsaicin on the celiac/mesenteric ganglia (10-21 days before) reduced gastric ileus by 33 ± 8%, whereas perivagal capsaicin had no effect. The IV CGRP-induced inhibition of gastric emptying was completely reversed by the CGRP antagonist, CGRP(8-37) (30 μg, IV); CGRP(8-37) (15, 30, or 60 μg) or CGRP monoclonal antibody #4901 (2 mg protein) decreased the inhibition of gastric emptying by 11 ± 7%, 51 ± 13%, 47 ± 3%, and 45 ± 17%, respectively. These results indicate that CGRP and splanchnic capsaicin-sensitive afferents are involved in mediating part of the gastric ileus observed immediately after abdominal surgery.

Original languageEnglish (US)
Pages (from-to)1225-1229
Number of pages5
JournalPeptides
Volume14
Issue number6
DOIs
StatePublished - 1993

Keywords

  • Abdominal surgery
  • Capsaicin
  • CCK
  • CGRP antagonist
  • CGRP antibody
  • MK-329
  • Splanchnic afferents
  • Substance P

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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