cGMP in mouse rods

The spatiotemporal dynamics underlying single photon responses

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Vertebrate vision begins when retinal photoreceptors transduce photons into electrical signals that are then relayed to other neurons in the eye, and ultimately to the brain. In rod photoreceptors, transduction of single photons is achieved by a well-understood G-protein cascade that modulates cGMP levels, and in turn, cGMP-sensitive inward current. The spatial extent and depth of the decline in cGMP during the single photon response (SPR) have been major issues in phototransduction research since the discovery that single photons elicit substantial and reproducible changes in membrane current. The spatial profile of cGMP decline during the SPR affects signal gain, and thus may contribute to reduction of trial-to-trial fluctuations in the SPR. Here we summarize the general principles of rod phototransduction, emphasizing recent advances in resolving the spatiotemporal dynamics of cGMP during the SPR.

Original languageEnglish (US)
JournalFrontiers in Molecular Neuroscience
Volume8
Issue numberMAR
DOIs
StatePublished - Mar 4 2015

Fingerprint

Photons
Light Signal Transduction
Retinal Rod Photoreceptor Cells
Vertebrate Photoreceptor Cells
GTP-Binding Proteins
Vertebrates
Neurons
Membranes
Brain
Research

Keywords

  • Photoreceptor
  • Phototransduction
  • Rhodopsin
  • Rod
  • Vision

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Molecular Biology

Cite this

cGMP in mouse rods : The spatiotemporal dynamics underlying single photon responses. / Gross, Owen P.; Pugh Jr, Edward N; Burns, Marie E.

In: Frontiers in Molecular Neuroscience, Vol. 8, No. MAR, 04.03.2015.

Research output: Contribution to journalArticle

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