Abstract
AMP-activated protein kinase (AMPK) is a eukaryotic energy sensor and protector from mitochondrial/energetic stress that is also a therapeutic target for cancer and metabolic disease. Metformin is an AMPK inducer that has been used in cancer therapeutic trials. Through screening we isolated cetylpyridinium chloride (CPC), a drug known to dose-dependently inhibit mitochondrial complex 1, as a potent and dose-dependent AMPK stimulator. Mitochondrial biogenesis and bioenergetics changes have also been implicated in glioblastoma, which is the most aggressive form of brain tumors. Cetylpyridinium chloride has been administered in humans as a safe drug-disinfectant for several decades, and we report here that under in vitro conditions, cetylpyridinium chloride kills glioblastoma cells in a dose dependent manner at a higher efficacy compared to current standard of care drug, temozolomide.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 19-24 |
| Number of pages | 6 |
| Journal | Mitochondrion |
| Volume | 50 |
| DOIs | |
| State | Published - Jan 2020 |
Fingerprint
Keywords
- AMP-activated protein kinase
- AMPK
- Cancer
- Cetylpyridinium chloride
- Mitochondrial inhibitor
- Quaternary ammonium salt
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Cell Biology
Cite this
Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer. / Allen, Sonia A.; Datta, Sandipan; Sandoval, Jose; Tomilov, Alexey; Sears, Thomas; Woolard, Kevin; Angelastro, James M.; Cortopassi, Gino A.
In: Mitochondrion, Vol. 50, 01.2020, p. 19-24.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer
AU - Allen, Sonia A.
AU - Datta, Sandipan
AU - Sandoval, Jose
AU - Tomilov, Alexey
AU - Sears, Thomas
AU - Woolard, Kevin
AU - Angelastro, James M.
AU - Cortopassi, Gino A.
PY - 2020/1
Y1 - 2020/1
N2 - AMP-activated protein kinase (AMPK) is a eukaryotic energy sensor and protector from mitochondrial/energetic stress that is also a therapeutic target for cancer and metabolic disease. Metformin is an AMPK inducer that has been used in cancer therapeutic trials. Through screening we isolated cetylpyridinium chloride (CPC), a drug known to dose-dependently inhibit mitochondrial complex 1, as a potent and dose-dependent AMPK stimulator. Mitochondrial biogenesis and bioenergetics changes have also been implicated in glioblastoma, which is the most aggressive form of brain tumors. Cetylpyridinium chloride has been administered in humans as a safe drug-disinfectant for several decades, and we report here that under in vitro conditions, cetylpyridinium chloride kills glioblastoma cells in a dose dependent manner at a higher efficacy compared to current standard of care drug, temozolomide.
AB - AMP-activated protein kinase (AMPK) is a eukaryotic energy sensor and protector from mitochondrial/energetic stress that is also a therapeutic target for cancer and metabolic disease. Metformin is an AMPK inducer that has been used in cancer therapeutic trials. Through screening we isolated cetylpyridinium chloride (CPC), a drug known to dose-dependently inhibit mitochondrial complex 1, as a potent and dose-dependent AMPK stimulator. Mitochondrial biogenesis and bioenergetics changes have also been implicated in glioblastoma, which is the most aggressive form of brain tumors. Cetylpyridinium chloride has been administered in humans as a safe drug-disinfectant for several decades, and we report here that under in vitro conditions, cetylpyridinium chloride kills glioblastoma cells in a dose dependent manner at a higher efficacy compared to current standard of care drug, temozolomide.
KW - AMP-activated protein kinase
KW - AMPK
KW - Cancer
KW - Cetylpyridinium chloride
KW - Mitochondrial inhibitor
KW - Quaternary ammonium salt
UR - http://www.scopus.com/inward/record.url?scp=85074173986&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85074173986&partnerID=8YFLogxK
U2 - 10.1016/j.mito.2019.09.009
DO - 10.1016/j.mito.2019.09.009
M3 - Article
C2 - 31654752
AN - SCOPUS:85074173986
VL - 50
SP - 19
EP - 24
JO - Mitochondrion
JF - Mitochondrion
SN - 1567-7249
ER -