Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer

Sonia A. Allen, Sandipan Datta, Jose Sandoval, Alexey Tomilov, Thomas Sears, Kevin Woolard, James M. Angelastro, Gino A. Cortopassi

Research output: Contribution to journalArticle

Abstract

AMP-activated protein kinase (AMPK) is a eukaryotic energy sensor and protector from mitochondrial/energetic stress that is also a therapeutic target for cancer and metabolic disease. Metformin is an AMPK inducer that has been used in cancer therapeutic trials. Through screening we isolated cetylpyridinium chloride (CPC), a drug known to dose-dependently inhibit mitochondrial complex 1, as a potent and dose-dependent AMPK stimulator. Mitochondrial biogenesis and bioenergetics changes have also been implicated in glioblastoma, which is the most aggressive form of brain tumors. Cetylpyridinium chloride has been administered in humans as a safe drug-disinfectant for several decades, and we report here that under in vitro conditions, cetylpyridinium chloride kills glioblastoma cells in a dose dependent manner at a higher efficacy compared to current standard of care drug, temozolomide.

Original languageEnglish (US)
Pages (from-to)19-24
Number of pages6
JournalMitochondrion
Volume50
DOIs
StatePublished - Jan 2020

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Cetylpyridinium
AMP-Activated Protein Kinases
temozolomide
Glioblastoma
Pharmaceutical Preparations
Neoplasms
Disinfectants
Metformin
Metabolic Diseases
Organelle Biogenesis
Standard of Care
Brain Neoplasms
Energy Metabolism
Therapeutics

Keywords

  • AMP-activated protein kinase
  • AMPK
  • Cancer
  • Cetylpyridinium chloride
  • Mitochondrial inhibitor
  • Quaternary ammonium salt

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

Cite this

Cetylpyridinium chloride is a potent AMP-activated kinase (AMPK) inducer and has therapeutic potential in cancer. / Allen, Sonia A.; Datta, Sandipan; Sandoval, Jose; Tomilov, Alexey; Sears, Thomas; Woolard, Kevin; Angelastro, James M.; Cortopassi, Gino A.

In: Mitochondrion, Vol. 50, 01.2020, p. 19-24.

Research output: Contribution to journalArticle

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