Cervicovaginal colposcopic lesions associated with 5 nonoxynol-9 vaginal spermicide formulations

Bryna Harwood, Leslie A. Meyn, Susan A. Ballagh, Elizabeth G. Raymond, David F. Archer, Mitchell D Creinin

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Objective: This study was undertaken to compare the colposcopic appearance of the cervicovaginal epithelium with spermicide use vs condom use in a low-risk population. Study Design: This was an ancillary study of a trial comparing the efficacy of 5 nonoxynol-9 spermicides. A cohort of women who used condoms without spermicide served as a control group. Colposcopic examinations were performed during product use to identify genital lesions. Results: One hundred fifty-one participants had 1 or more follow-up examinations. At baseline, study groups differed only by the prevalence of baseline lesions. New lesions were identified at 49% of follow-up visits. Controlling for the presence of a baseline lesion, compared with condom use none of the spermicides were associated with an increase in new lesions (overall odds ratio, 0.8; 95% CI, 0.4-1.6; P = .5); and lesions characterized by epithelial disruption were less frequent with spermicide use (overall odds ratio, 0.3; 95% CI, 0.1-0.6; P < .001). Conclusion: In a low-risk population, women who used nonoxynol-9 spermicides were less likely to have lesions with epithelial disruption, and equally likely to have any new lesion compared with condom use.

Original languageEnglish (US)
JournalAmerican Journal of Obstetrics and Gynecology
Issue number1
StatePublished - Jan 2008
Externally publishedYes


  • colposcopy
  • epithelial disruption
  • nonoxynol-9
  • vaginal spermicides

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology


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