Cerenkov luminescence tomography for small-animal imaging

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Abstract

Cerenkov radiation is a well-known phenomenon in which optical photons are emitted by charged particles moving faster than the speed of light in a medium. We have observed Cerenkov photons emitted from β-emitting radiotracers such as 18F-fluorodeoxyglucose using a sensitive CCD camera. Phantom and in vivo mouse imaging experiments have demonstrated that surface measurements of the emitted Cerenkov optical photons could be used to reconstruct the radiotracer activity distribution inside an object by modeling the optical photon propagation with the diffusion equation and reconstructing the optical emission source distribution iteratively with a preconditioned conjugate gradient method.

Original languageEnglish (US)
Pages (from-to)1109-1111
Number of pages3
JournalOptics Letters
Volume35
Issue number7
StatePublished - Apr 1 2010

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ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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