Cerenkov luminescence tomography for small-animal imaging

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Cerenkov radiation is a well-known phenomenon in which optical photons are emitted by charged particles moving faster than the speed of light in a medium. We have observed Cerenkov photons emitted from β-emitting radiotracers such as 18F-fluorodeoxyglucose using a sensitive CCD camera. Phantom and in vivo mouse imaging experiments have demonstrated that surface measurements of the emitted Cerenkov optical photons could be used to reconstruct the radiotracer activity distribution inside an object by modeling the optical photon propagation with the diffusion equation and reconstructing the optical emission source distribution iteratively with a preconditioned conjugate gradient method.

Original languageEnglish (US)
Pages (from-to)1109-1111
Number of pages3
JournalOptics Letters
Volume35
Issue number7
StatePublished - Apr 1 2010

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animals
tomography
luminescence
photons
Cerenkov radiation
conjugate gradient method
CCD cameras
light emission
mice
charged particles
propagation

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Cerenkov luminescence tomography for small-animal imaging. / Li, Changqing; Mitchell, Gregory; Cherry, Simon R.

In: Optics Letters, Vol. 35, No. 7, 01.04.2010, p. 1109-1111.

Research output: Contribution to journalArticle

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