Abstract
Cerenkov radiation is a well-known phenomenon in which optical photons are emitted by charged particles moving faster than the speed of light in a medium. We have observed Cerenkov photons emitted from β-emitting radiotracers such as 18F-fluorodeoxyglucose using a sensitive CCD camera. Phantom and in vivo mouse imaging experiments have demonstrated that surface measurements of the emitted Cerenkov optical photons could be used to reconstruct the radiotracer activity distribution inside an object by modeling the optical photon propagation with the diffusion equation and reconstructing the optical emission source distribution iteratively with a preconditioned conjugate gradient method.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1109-1111 |
| Number of pages | 3 |
| Journal | Optics Letters |
| Volume | 35 |
| Issue number | 7 |
| State | Published - Apr 1 2010 |
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ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
Cite this
Cerenkov luminescence tomography for small-animal imaging. / Li, Changqing; Mitchell, Gregory; Cherry, Simon R.
In: Optics Letters, Vol. 35, No. 7, 01.04.2010, p. 1109-1111.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cerenkov luminescence tomography for small-animal imaging
AU - Li, Changqing
AU - Mitchell, Gregory
AU - Cherry, Simon R
PY - 2010/4/1
Y1 - 2010/4/1
N2 - Cerenkov radiation is a well-known phenomenon in which optical photons are emitted by charged particles moving faster than the speed of light in a medium. We have observed Cerenkov photons emitted from β-emitting radiotracers such as 18F-fluorodeoxyglucose using a sensitive CCD camera. Phantom and in vivo mouse imaging experiments have demonstrated that surface measurements of the emitted Cerenkov optical photons could be used to reconstruct the radiotracer activity distribution inside an object by modeling the optical photon propagation with the diffusion equation and reconstructing the optical emission source distribution iteratively with a preconditioned conjugate gradient method.
AB - Cerenkov radiation is a well-known phenomenon in which optical photons are emitted by charged particles moving faster than the speed of light in a medium. We have observed Cerenkov photons emitted from β-emitting radiotracers such as 18F-fluorodeoxyglucose using a sensitive CCD camera. Phantom and in vivo mouse imaging experiments have demonstrated that surface measurements of the emitted Cerenkov optical photons could be used to reconstruct the radiotracer activity distribution inside an object by modeling the optical photon propagation with the diffusion equation and reconstructing the optical emission source distribution iteratively with a preconditioned conjugate gradient method.
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UR - http://www.scopus.com/inward/citedby.url?scp=77954730550&partnerID=8YFLogxK
M3 - Article
C2 - 20364233
AN - SCOPUS:77954730550
VL - 35
SP - 1109
EP - 1111
JO - Optics Letters
JF - Optics Letters
SN - 0146-9592
IS - 7
ER -