Cerenkov luminescence and PET imaging of 90Y: Capabilities and limitations in small animal applications

Research output: Contribution to journalArticle

Abstract

The in vivo sensitivity limits and quantification performance of Cerenkov luminescence imaging have been studied using a tissue-like mouse phantom and 90Y. For a small, 9 mm deep target in the phantom, with no background activity present, the Cerenkov luminescence 90Y detection limit determined from contrast-to-noise ratios is 10 nCi for a 2 min exposure with a sensitive CCD camera and no filters. For quantitative performance, the values extracted from regions of interest on the images are linear within 5% of a straight line fit versus target activity for target activity of 70 nCi and above. The small branching ratio to decay with positron emission for 90Y also permits low-statistics PET imaging of the radionuclide. For PET imaging of the same phantom, with a small animal LSO detector-based scanner, the 90Y detection limit is approximately 3 orders of magnitude higher at 10 µCi.

Original languageEnglish (US)
Article number065006
JournalPhysics in medicine and biology
Volume65
Issue number6
DOIs
StatePublished - Jan 1 2020

Keywords

  • Cerenkov luminescence
  • Cerenkov radiation
  • optical imaging
  • yttrium-90 imaging

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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