Cerebrovascular disease, beta-amyloid, and cognition in aging

Natalie L. Marchant, Bruce R Reed, Charles DeCarli, Cindee M. Madison, Michael W. Weiner, Helena C. Chui, William J. Jagust

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


The present study evaluated cerebrovascular disease (CVD), β-amyloid (Aβ), and cognition in clinically normal elderly adults. Fifty-four participants underwent magnetic resonance imaging (MRI), Pittsburgh compound B (PIB)-positron emission tomography (PET) imaging, and neuropsychological evaluation. High white matter hyperintensity burden and/or presence of infarct defined CVD status (CVD-: n = 27; CVD+: n = 27). PIB-positron emission tomography ratios of Aβ deposition were extracted using Logan plotting (cerebellar reference). Presence of high levels of Aβ in prespecified regions determined PIB status (PIB-: n = 33; PIB+: n = 21). Executive functioning and episodic memory were measured using composite scales. CVD and Aβ, defined as dichotomous or continuous variables, were unrelated to one another. CVD+ participants showed lower executive functioning (p = 0.001) when compared with CVD- individuals. Neither PIB status nor amount of Aβ affected cognition (ps ≥ 0.45), and there was no statistical interaction between CVD and PIB on either cognitive measure. Within this spectrum of normal aging CVD and Aβ aggregation appear to be independent processes with CVD primarily affecting cognition.

Original languageEnglish (US)
Pages (from-to)1006.e25-1006.e36
JournalNeurobiology of Aging
Issue number5
StatePublished - Jan 1 2012


  • Cerebrovascular disease
  • Cognition
  • Episodic memory
  • Executive functioning
  • PIB

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


Dive into the research topics of 'Cerebrovascular disease, beta-amyloid, and cognition in aging'. Together they form a unique fingerprint.

Cite this