Cerebrospinal latex agglutination fails to contribute to the microbiologic diagnosis of pretreated children with meningitis

Lise E. Nigrovic, Nathan Kuppermann, Alexander J. McAdam, Richard Malley

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

We conducted a 10-year retrospective study of all children who had cerebrospinal fluid latex agglutination testing for bacterial antigens performed at 1 tertiary care urban children's hospital. Of the 176 patients with culture-negative meningitis who were pretreated with antibiotics before lumbar puncture, none had a positive latex agglutination study (0 of 176; 95% confidence interval, 0-2%). Latex agglutination studies identified no additional cases of bacterial meningitis beyond those identified by culture in pretreated patients. Clinical decision-making algorithms for the management of pretreated patients at risk for bacterial meningitis should not include latex agglutination testing.

Original languageEnglish (US)
Pages (from-to)786-788
Number of pages3
JournalPediatric Infectious Disease Journal
Volume23
Issue number8
DOIs
StatePublished - Aug 2004

Keywords

  • Diagnostic tests
  • Latex agglutination
  • Meningitis
  • Pretreatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)

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