Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementia

Owen T. Carmichael, Lewis H. Kuller, Oscar L. Lopez, Paul M. Thompson, Rebecca A. Dutton, Allen Lu, Sharon E. Lee, Jessica Y. Lee, Howard J. Aizenstein, Carolyn C. Meltzer, Yanxi Liu, Arthur W. Toga, James T. Becker

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Expansion of the cerebral ventricles may occur at an accelerated rate in subjects with dementia, but the time course of expansion during transitions between normal cognitive function, mild cognitive impairment (MCI), and dementia is not well understood. Furthermore, the effects of cardiovascular risk factors on rate of ventricular expansion are unclear. We used a fully automated segmentation technique to measure change rate in lateral ventricle-to-brain ratio (VBR) on 145 longitudinal pairs of magnetic resonance images of subjects in the Cardiovascular Health Study Cognition Study from the Pittsburgh Center. A multivariate model analyzed VBR change rate, accounting for dementia statuses at both imaging times (normal, MCI, or dementia), age, sex, education, race, magnetic resonance-defined infarcts, Center for Epidemiology Studies Depression Scale, baseline ventricular volume, and cardiovascular risk factors. VBR change was faster in subjects who were demented or transitioned from MCI to dementia, compared with subjects normal at both images and subjects who transitioned from normal to MCI or dementia. Patients with diabetes had faster VBR change. Ventricular expansion may accelerate late in the progression from normal cognitive function to dementia, and may be modulated by diabetes.

Original languageEnglish (US)
Pages (from-to)14-24
Number of pages11
JournalAlzheimer Disease and Associated Disorders
Volume21
Issue number1
DOIs
StatePublished - Jan 2007

Fingerprint

Cognition
Dementia
Brain
Magnetic Resonance Spectroscopy
Cerebral Ventricles
Sex Education
Lateral Ventricles
Cognitive Dysfunction
Epidemiology
Depression
Health

Keywords

  • Automated segmentation
  • Dementia
  • Lateral ventricles
  • Magnetic resonance imaging
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementia. / Carmichael, Owen T.; Kuller, Lewis H.; Lopez, Oscar L.; Thompson, Paul M.; Dutton, Rebecca A.; Lu, Allen; Lee, Sharon E.; Lee, Jessica Y.; Aizenstein, Howard J.; Meltzer, Carolyn C.; Liu, Yanxi; Toga, Arthur W.; Becker, James T.

In: Alzheimer Disease and Associated Disorders, Vol. 21, No. 1, 01.2007, p. 14-24.

Research output: Contribution to journalArticle

Carmichael, OT, Kuller, LH, Lopez, OL, Thompson, PM, Dutton, RA, Lu, A, Lee, SE, Lee, JY, Aizenstein, HJ, Meltzer, CC, Liu, Y, Toga, AW & Becker, JT 2007, 'Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementia', Alzheimer Disease and Associated Disorders, vol. 21, no. 1, pp. 14-24. https://doi.org/10.1097/WAD.0b013e318032d2b1
Carmichael, Owen T. ; Kuller, Lewis H. ; Lopez, Oscar L. ; Thompson, Paul M. ; Dutton, Rebecca A. ; Lu, Allen ; Lee, Sharon E. ; Lee, Jessica Y. ; Aizenstein, Howard J. ; Meltzer, Carolyn C. ; Liu, Yanxi ; Toga, Arthur W. ; Becker, James T. / Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementia. In: Alzheimer Disease and Associated Disorders. 2007 ; Vol. 21, No. 1. pp. 14-24.
@article{a2ff41de939a41a388cd97d1e519b7ea,
title = "Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementia",
abstract = "Expansion of the cerebral ventricles may occur at an accelerated rate in subjects with dementia, but the time course of expansion during transitions between normal cognitive function, mild cognitive impairment (MCI), and dementia is not well understood. Furthermore, the effects of cardiovascular risk factors on rate of ventricular expansion are unclear. We used a fully automated segmentation technique to measure change rate in lateral ventricle-to-brain ratio (VBR) on 145 longitudinal pairs of magnetic resonance images of subjects in the Cardiovascular Health Study Cognition Study from the Pittsburgh Center. A multivariate model analyzed VBR change rate, accounting for dementia statuses at both imaging times (normal, MCI, or dementia), age, sex, education, race, magnetic resonance-defined infarcts, Center for Epidemiology Studies Depression Scale, baseline ventricular volume, and cardiovascular risk factors. VBR change was faster in subjects who were demented or transitioned from MCI to dementia, compared with subjects normal at both images and subjects who transitioned from normal to MCI or dementia. Patients with diabetes had faster VBR change. Ventricular expansion may accelerate late in the progression from normal cognitive function to dementia, and may be modulated by diabetes.",
keywords = "Automated segmentation, Dementia, Lateral ventricles, Magnetic resonance imaging, Mild cognitive impairment",
author = "Carmichael, {Owen T.} and Kuller, {Lewis H.} and Lopez, {Oscar L.} and Thompson, {Paul M.} and Dutton, {Rebecca A.} and Allen Lu and Lee, {Sharon E.} and Lee, {Jessica Y.} and Aizenstein, {Howard J.} and Meltzer, {Carolyn C.} and Yanxi Liu and Toga, {Arthur W.} and Becker, {James T.}",
year = "2007",
month = "1",
doi = "10.1097/WAD.0b013e318032d2b1",
language = "English (US)",
volume = "21",
pages = "14--24",
journal = "Alzheimer Disease and Associated Disorders",
issn = "0893-0341",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementia

AU - Carmichael, Owen T.

AU - Kuller, Lewis H.

AU - Lopez, Oscar L.

AU - Thompson, Paul M.

AU - Dutton, Rebecca A.

AU - Lu, Allen

AU - Lee, Sharon E.

AU - Lee, Jessica Y.

AU - Aizenstein, Howard J.

AU - Meltzer, Carolyn C.

AU - Liu, Yanxi

AU - Toga, Arthur W.

AU - Becker, James T.

PY - 2007/1

Y1 - 2007/1

N2 - Expansion of the cerebral ventricles may occur at an accelerated rate in subjects with dementia, but the time course of expansion during transitions between normal cognitive function, mild cognitive impairment (MCI), and dementia is not well understood. Furthermore, the effects of cardiovascular risk factors on rate of ventricular expansion are unclear. We used a fully automated segmentation technique to measure change rate in lateral ventricle-to-brain ratio (VBR) on 145 longitudinal pairs of magnetic resonance images of subjects in the Cardiovascular Health Study Cognition Study from the Pittsburgh Center. A multivariate model analyzed VBR change rate, accounting for dementia statuses at both imaging times (normal, MCI, or dementia), age, sex, education, race, magnetic resonance-defined infarcts, Center for Epidemiology Studies Depression Scale, baseline ventricular volume, and cardiovascular risk factors. VBR change was faster in subjects who were demented or transitioned from MCI to dementia, compared with subjects normal at both images and subjects who transitioned from normal to MCI or dementia. Patients with diabetes had faster VBR change. Ventricular expansion may accelerate late in the progression from normal cognitive function to dementia, and may be modulated by diabetes.

AB - Expansion of the cerebral ventricles may occur at an accelerated rate in subjects with dementia, but the time course of expansion during transitions between normal cognitive function, mild cognitive impairment (MCI), and dementia is not well understood. Furthermore, the effects of cardiovascular risk factors on rate of ventricular expansion are unclear. We used a fully automated segmentation technique to measure change rate in lateral ventricle-to-brain ratio (VBR) on 145 longitudinal pairs of magnetic resonance images of subjects in the Cardiovascular Health Study Cognition Study from the Pittsburgh Center. A multivariate model analyzed VBR change rate, accounting for dementia statuses at both imaging times (normal, MCI, or dementia), age, sex, education, race, magnetic resonance-defined infarcts, Center for Epidemiology Studies Depression Scale, baseline ventricular volume, and cardiovascular risk factors. VBR change was faster in subjects who were demented or transitioned from MCI to dementia, compared with subjects normal at both images and subjects who transitioned from normal to MCI or dementia. Patients with diabetes had faster VBR change. Ventricular expansion may accelerate late in the progression from normal cognitive function to dementia, and may be modulated by diabetes.

KW - Automated segmentation

KW - Dementia

KW - Lateral ventricles

KW - Magnetic resonance imaging

KW - Mild cognitive impairment

UR - http://www.scopus.com/inward/record.url?scp=33947116869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947116869&partnerID=8YFLogxK

U2 - 10.1097/WAD.0b013e318032d2b1

DO - 10.1097/WAD.0b013e318032d2b1

M3 - Article

C2 - 17334268

AN - SCOPUS:33947116869

VL - 21

SP - 14

EP - 24

JO - Alzheimer Disease and Associated Disorders

JF - Alzheimer Disease and Associated Disorders

SN - 0893-0341

IS - 1

ER -