Abstract
Cerebral salt wasting (CSW) is a syndrome of hypovolemic hyponatremia caused by natriuresis and diuresis. The mechanisms underlying CSW have not been precisely delineated, although existing evidence strongly implicates abnormal elevations in circulating natriuretic peptides. The key in diagnosis of CSW lies in distinguishing it from the more common syndrome of inappropriate secretion of antidiuretic hormone. Volume status, but not serum and urine electrolytes and osmolality, is crucial for making this distinction. Volume and sodium repletion are the goals of treatment of patients with CSW, and this can be performed using some combination of isotonic saline, hypertonic saline, and mineralocorticoids.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 339-352 |
| Number of pages | 14 |
| Journal | Neurosurgery Clinics of North America |
| Volume | 21 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1 2010 |
| Externally published | Yes |
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Keywords
- Hyponatremia
- Natriuresis
- Natriuretic factors
- SIADH
ASJC Scopus subject areas
- Clinical Neurology
- Surgery
Cite this
Cerebral Salt Wasting : Pathophysiology, Diagnosis, and Treatment. / Yee, Alan Howe; Burns, Joseph D.; Wijdicks, E. F M.
In: Neurosurgery Clinics of North America, Vol. 21, No. 2, 01.04.2010, p. 339-352.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Cerebral Salt Wasting
T2 - Pathophysiology, Diagnosis, and Treatment
AU - Yee, Alan Howe
AU - Burns, Joseph D.
AU - Wijdicks, E. F M
PY - 2010/4/1
Y1 - 2010/4/1
N2 - Cerebral salt wasting (CSW) is a syndrome of hypovolemic hyponatremia caused by natriuresis and diuresis. The mechanisms underlying CSW have not been precisely delineated, although existing evidence strongly implicates abnormal elevations in circulating natriuretic peptides. The key in diagnosis of CSW lies in distinguishing it from the more common syndrome of inappropriate secretion of antidiuretic hormone. Volume status, but not serum and urine electrolytes and osmolality, is crucial for making this distinction. Volume and sodium repletion are the goals of treatment of patients with CSW, and this can be performed using some combination of isotonic saline, hypertonic saline, and mineralocorticoids.
AB - Cerebral salt wasting (CSW) is a syndrome of hypovolemic hyponatremia caused by natriuresis and diuresis. The mechanisms underlying CSW have not been precisely delineated, although existing evidence strongly implicates abnormal elevations in circulating natriuretic peptides. The key in diagnosis of CSW lies in distinguishing it from the more common syndrome of inappropriate secretion of antidiuretic hormone. Volume status, but not serum and urine electrolytes and osmolality, is crucial for making this distinction. Volume and sodium repletion are the goals of treatment of patients with CSW, and this can be performed using some combination of isotonic saline, hypertonic saline, and mineralocorticoids.
KW - Hyponatremia
KW - Natriuresis
KW - Natriuretic factors
KW - SIADH
UR - http://www.scopus.com/inward/record.url?scp=77951043679&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951043679&partnerID=8YFLogxK
U2 - 10.1016/j.nec.2009.10.011
DO - 10.1016/j.nec.2009.10.011
M3 - Review article
VL - 21
SP - 339
EP - 352
JO - Neurosurgery Clinics of North America
JF - Neurosurgery Clinics of North America
SN - 1042-3680
IS - 2
ER -