Cerebral Salt Wasting: Pathophysiology, Diagnosis, and Treatment

Alan Howe Yee, Joseph D. Burns, E. F M Wijdicks

Research output: Contribution to journalReview article

86 Scopus citations

Abstract

Cerebral salt wasting (CSW) is a syndrome of hypovolemic hyponatremia caused by natriuresis and diuresis. The mechanisms underlying CSW have not been precisely delineated, although existing evidence strongly implicates abnormal elevations in circulating natriuretic peptides. The key in diagnosis of CSW lies in distinguishing it from the more common syndrome of inappropriate secretion of antidiuretic hormone. Volume status, but not serum and urine electrolytes and osmolality, is crucial for making this distinction. Volume and sodium repletion are the goals of treatment of patients with CSW, and this can be performed using some combination of isotonic saline, hypertonic saline, and mineralocorticoids.

Original languageEnglish (US)
Pages (from-to)339-352
Number of pages14
JournalNeurosurgery Clinics of North America
Volume21
Issue number2
DOIs
StatePublished - Apr 1 2010
Externally publishedYes

Keywords

  • Hyponatremia
  • Natriuresis
  • Natriuretic factors
  • SIADH

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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