Cerebral microgyria in a 27 week fetus: an architectonic and topographic analysis

David P Richman, R. M. Stewart, V. S. Caviness

Research output: Contribution to journalArticle

117 Scopus citations

Abstract

The cytoarchitecture and topography of a case of restricted cerebral microgyria in a 27 wk fetus were analyzed in whole brain serial sections. The cytoarchitectonic features of the four microgyric layers and their continuity with the layers of normal cortex imply that microgyria is the result of a post-migratory encephaloclastic event resulting in laminar destruction of the middle cortical layers. The distribution of the abnormality in this and other cases suggests that the etiology of this laminar destruction may be intra-uterine hypoxia or perfusion failure.

Original languageEnglish (US)
Pages (from-to)374-384
Number of pages11
JournalJournal of Neuropathology and Experimental Neurology
Volume33
Issue number3
StatePublished - 1974
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

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