The cytoarchitecture and topography of a case of restricted cerebral microgyria in a 27 wk fetus were analyzed in whole brain serial sections. The cytoarchitectonic features of the four microgyric layers and their continuity with the layers of normal cortex imply that microgyria is the result of a post-migratory encephaloclastic event resulting in laminar destruction of the middle cortical layers. The distribution of the abnormality in this and other cases suggests that the etiology of this laminar destruction may be intra-uterine hypoxia or perfusion failure.
|Original language||English (US)|
|Number of pages||11|
|Journal||Journal of Neuropathology and Experimental Neurology|
|State||Published - 1974|
ASJC Scopus subject areas
- Pathology and Forensic Medicine