Cerebral metabolism in the newborn lamb with polycythemia

T. S. Rosenkrantz, Anthony F Philipps, P. S. Skrzypczak, J. R. Raye

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Infants with polycythemia and hyperviscosity are known to have a reduced cerebral blood flow. Eight newborn lambs were studied to determine what effect the reduction in cerebral blood flow might have on the cerebral delivery and uptake of oxygen, glucose, lactate, pyruvate, β-hydroxybutyrate, and acetoacetate. Measurements of cerebral blood flow, hematocrit, blood viscosity as well as delivery and uptake of the forementioned substrates were made during a control period and at 60, 180, and 300min after an exchange transfusion with packed newborn red blood cells was performed to increase the hematocrit. Sixty min after the exchange transfusion, cerebral blood flow fell while cerebral oxygen delivery and uptake were stable. Although arterial glucose concentration remained unchanged, there was a significant fall in cerebral glucose delivery. At 180 min after the exchange transfusion, the arterial glucose concentration fell from 90 to 70 mg/100 ml causing the cerebral glucose delivery to further decrease. This resulted in a significant fall in the cerebral glucose uptake and glucose:oxygen quotient. At 300 min arterial glucose concentration remained low but a rise in cerebral blood flow resulted in a small increase in the cerebral glucose delivery and consequently the cerebral glucose uptake and glucose:oxygen quotient returned to normal. We conclude that polycythemia results in a decrease in cerebral glucose delivery and uptake during normoglycemia.

Original languageEnglish (US)
Pages (from-to)329-333
Number of pages5
JournalPediatric Research
Volume23
Issue number3
StatePublished - 1988
Externally publishedYes

Fingerprint

Polycythemia
Newborn Infant
Cerebrovascular Circulation
Glucose
Oxygen
Hematocrit
Hydroxybutyrates
Blood Viscosity
Pyruvic Acid
Lactic Acid
Erythrocytes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Rosenkrantz, T. S., Philipps, A. F., Skrzypczak, P. S., & Raye, J. R. (1988). Cerebral metabolism in the newborn lamb with polycythemia. Pediatric Research, 23(3), 329-333.

Cerebral metabolism in the newborn lamb with polycythemia. / Rosenkrantz, T. S.; Philipps, Anthony F; Skrzypczak, P. S.; Raye, J. R.

In: Pediatric Research, Vol. 23, No. 3, 1988, p. 329-333.

Research output: Contribution to journalArticle

Rosenkrantz, TS, Philipps, AF, Skrzypczak, PS & Raye, JR 1988, 'Cerebral metabolism in the newborn lamb with polycythemia', Pediatric Research, vol. 23, no. 3, pp. 329-333.
Rosenkrantz TS, Philipps AF, Skrzypczak PS, Raye JR. Cerebral metabolism in the newborn lamb with polycythemia. Pediatric Research. 1988;23(3):329-333.
Rosenkrantz, T. S. ; Philipps, Anthony F ; Skrzypczak, P. S. ; Raye, J. R. / Cerebral metabolism in the newborn lamb with polycythemia. In: Pediatric Research. 1988 ; Vol. 23, No. 3. pp. 329-333.
@article{8e8367bb9ab64ac5ac8fd32616aa509a,
title = "Cerebral metabolism in the newborn lamb with polycythemia",
abstract = "Infants with polycythemia and hyperviscosity are known to have a reduced cerebral blood flow. Eight newborn lambs were studied to determine what effect the reduction in cerebral blood flow might have on the cerebral delivery and uptake of oxygen, glucose, lactate, pyruvate, β-hydroxybutyrate, and acetoacetate. Measurements of cerebral blood flow, hematocrit, blood viscosity as well as delivery and uptake of the forementioned substrates were made during a control period and at 60, 180, and 300min after an exchange transfusion with packed newborn red blood cells was performed to increase the hematocrit. Sixty min after the exchange transfusion, cerebral blood flow fell while cerebral oxygen delivery and uptake were stable. Although arterial glucose concentration remained unchanged, there was a significant fall in cerebral glucose delivery. At 180 min after the exchange transfusion, the arterial glucose concentration fell from 90 to 70 mg/100 ml causing the cerebral glucose delivery to further decrease. This resulted in a significant fall in the cerebral glucose uptake and glucose:oxygen quotient. At 300 min arterial glucose concentration remained low but a rise in cerebral blood flow resulted in a small increase in the cerebral glucose delivery and consequently the cerebral glucose uptake and glucose:oxygen quotient returned to normal. We conclude that polycythemia results in a decrease in cerebral glucose delivery and uptake during normoglycemia.",
author = "Rosenkrantz, {T. S.} and Philipps, {Anthony F} and Skrzypczak, {P. S.} and Raye, {J. R.}",
year = "1988",
language = "English (US)",
volume = "23",
pages = "329--333",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Cerebral metabolism in the newborn lamb with polycythemia

AU - Rosenkrantz, T. S.

AU - Philipps, Anthony F

AU - Skrzypczak, P. S.

AU - Raye, J. R.

PY - 1988

Y1 - 1988

N2 - Infants with polycythemia and hyperviscosity are known to have a reduced cerebral blood flow. Eight newborn lambs were studied to determine what effect the reduction in cerebral blood flow might have on the cerebral delivery and uptake of oxygen, glucose, lactate, pyruvate, β-hydroxybutyrate, and acetoacetate. Measurements of cerebral blood flow, hematocrit, blood viscosity as well as delivery and uptake of the forementioned substrates were made during a control period and at 60, 180, and 300min after an exchange transfusion with packed newborn red blood cells was performed to increase the hematocrit. Sixty min after the exchange transfusion, cerebral blood flow fell while cerebral oxygen delivery and uptake were stable. Although arterial glucose concentration remained unchanged, there was a significant fall in cerebral glucose delivery. At 180 min after the exchange transfusion, the arterial glucose concentration fell from 90 to 70 mg/100 ml causing the cerebral glucose delivery to further decrease. This resulted in a significant fall in the cerebral glucose uptake and glucose:oxygen quotient. At 300 min arterial glucose concentration remained low but a rise in cerebral blood flow resulted in a small increase in the cerebral glucose delivery and consequently the cerebral glucose uptake and glucose:oxygen quotient returned to normal. We conclude that polycythemia results in a decrease in cerebral glucose delivery and uptake during normoglycemia.

AB - Infants with polycythemia and hyperviscosity are known to have a reduced cerebral blood flow. Eight newborn lambs were studied to determine what effect the reduction in cerebral blood flow might have on the cerebral delivery and uptake of oxygen, glucose, lactate, pyruvate, β-hydroxybutyrate, and acetoacetate. Measurements of cerebral blood flow, hematocrit, blood viscosity as well as delivery and uptake of the forementioned substrates were made during a control period and at 60, 180, and 300min after an exchange transfusion with packed newborn red blood cells was performed to increase the hematocrit. Sixty min after the exchange transfusion, cerebral blood flow fell while cerebral oxygen delivery and uptake were stable. Although arterial glucose concentration remained unchanged, there was a significant fall in cerebral glucose delivery. At 180 min after the exchange transfusion, the arterial glucose concentration fell from 90 to 70 mg/100 ml causing the cerebral glucose delivery to further decrease. This resulted in a significant fall in the cerebral glucose uptake and glucose:oxygen quotient. At 300 min arterial glucose concentration remained low but a rise in cerebral blood flow resulted in a small increase in the cerebral glucose delivery and consequently the cerebral glucose uptake and glucose:oxygen quotient returned to normal. We conclude that polycythemia results in a decrease in cerebral glucose delivery and uptake during normoglycemia.

UR - http://www.scopus.com/inward/record.url?scp=0023853333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023853333&partnerID=8YFLogxK

M3 - Article

C2 - 3353180

AN - SCOPUS:0023853333

VL - 23

SP - 329

EP - 333

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 3

ER -