Cerebral metabolism, cognition, and functional abilities in Alzheimer disease

Rebecca J. Melrose, Mark L. Ettenhofer, Dylan Harwood, Natalie Achamallah, Olivia Campa, Mark Mandelkern, David L. Sultzer

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Patients with Alzheimer disease (AD) exhibit profound difficulties in completing instrumental activities of daily living (IADLs), such as managing finances, organizing medications, and food preparation. It is unclear which brain areas underlie IADL deficits in AD. To address this question, we used voxel-based analysis to correlate the performance of IADLs with resting cerebral metabolism as measured during [18F] fluorodeoxyglucose-positron emission tomography (FDG-PET) imaging in 44 patients with AD. Poorer ability to complete IADLs was associated with hypometabolism in right-sided cortical regions, including the parietal lobe, posterior temporal cortex, dorsolateral prefrontal cortex, and frontal pole. Follow-up path analyses examining anatomically defined regions of interest (ROI) demonstrated that the association between metabolism and IADLs was mediated by global cognition in frontal ROIs, and partially mediated by global cognition in the parietal ROI. Findings suggest that hypometabolism of right sided brain regions involved in executive functioning, visuospatial processing, attention, and working memory underlie functional impairments in patients with AD.

Original languageEnglish (US)
Pages (from-to)127-134
Number of pages8
JournalJournal of Geriatric Psychiatry and Neurology
Volume24
Issue number3
DOIs
StatePublished - Sep 1 2011
Externally publishedYes

Fingerprint

Aptitude
Activities of Daily Living
Cognition
Alzheimer Disease
Parietal Lobe
Fluorodeoxyglucose F18
Brain
Temporal Lobe
Prefrontal Cortex
Short-Term Memory
Positron-Emission Tomography
Food

Keywords

  • Alzheimer disease
  • cerebral metabolism
  • cognition
  • functional ability
  • IADLs

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Melrose, R. J., Ettenhofer, M. L., Harwood, D., Achamallah, N., Campa, O., Mandelkern, M., & Sultzer, D. L. (2011). Cerebral metabolism, cognition, and functional abilities in Alzheimer disease. Journal of Geriatric Psychiatry and Neurology, 24(3), 127-134. https://doi.org/10.1177/0891988711405333

Cerebral metabolism, cognition, and functional abilities in Alzheimer disease. / Melrose, Rebecca J.; Ettenhofer, Mark L.; Harwood, Dylan; Achamallah, Natalie; Campa, Olivia; Mandelkern, Mark; Sultzer, David L.

In: Journal of Geriatric Psychiatry and Neurology, Vol. 24, No. 3, 01.09.2011, p. 127-134.

Research output: Contribution to journalArticle

Melrose, RJ, Ettenhofer, ML, Harwood, D, Achamallah, N, Campa, O, Mandelkern, M & Sultzer, DL 2011, 'Cerebral metabolism, cognition, and functional abilities in Alzheimer disease', Journal of Geriatric Psychiatry and Neurology, vol. 24, no. 3, pp. 127-134. https://doi.org/10.1177/0891988711405333
Melrose, Rebecca J. ; Ettenhofer, Mark L. ; Harwood, Dylan ; Achamallah, Natalie ; Campa, Olivia ; Mandelkern, Mark ; Sultzer, David L. / Cerebral metabolism, cognition, and functional abilities in Alzheimer disease. In: Journal of Geriatric Psychiatry and Neurology. 2011 ; Vol. 24, No. 3. pp. 127-134.
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